Small molecules and extrinsic factors promoting differentiation of stem cells into insulin-producing cells.

Autor: Pan G; Department of Endocrinology, the Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Jiangxi Province, 330006 Nanchang, China., Liu J; Department of Endocrinology, the Second Affiliated Hospital of Nanchang University, No. 1, Minde Road, Jiangxi Province, 330006 Nanchang, China. Electronic address: liujpnfm@163.com.
Jazyk: angličtina
Zdroj: Annales d'endocrinologie [Ann Endocrinol (Paris)] 2019 Apr; Vol. 80 (2), pp. 128-133. Date of Electronic Publication: 2019 Jan 29.
DOI: 10.1016/j.ando.2018.11.002
Abstrakt: In the modern world, type-2 diabetes mellitus has become a leading public healthcare problem, due to major risks of morbidity and mortality. Prevalence has increased significantly in recent decades. Treatment involves oral hypoglycemic agents or insulin replacement therapy. Development is ongoing for cell-based diabetes therapies using stem cells with the potential to differentiate into insulin-producing cells (IPCs): embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and stem cells from adult pancreas, liver, central nervous system, bone marrow and adipose tissue. Successful induction of iPSCs, however, depends on the quantity and quality of available stem cells and the development of adapted protocols determining the environment of extrinsic factors and involvement of small molecules. Validating such new cell therapies must be founded on this experimental rationale.
(Copyright © 2019 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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