Neurolymphomatosis caused by T-cell lymphosarcoma in a cat: imaging description and treatment review.

Autor:	Beasley MJ; Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Hiebert EC; Sierra Veterinary Specialists and Emergency Center, Reno, NV, USA., Daw DN; Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Alexander KJ; Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA., Gambino JM; IDEXX Laboratories Inc., Clackamas, OR, USA.
Jazyk:	angličtina
Zdroj:	JFMS open reports [JFMS Open Rep] 2019 Feb 25; Vol. 5 (1), pp. 2055116919833534. Date of Electronic Publication: 2019 Feb 25 (Print Publication: 2019).
DOI:	10.1177/2055116919833534
Abstrakt:	Case Summary: A 16-year-old domestic shorthair cat was evaluated for acute-onset right pelvic limb monoparesis localized to the sciatic nerve. MRI revealed a homogeneously contrast-enhancing, well-demarcated mass effacing the right sciatic nerve from its intravertebral origin to the end of the viewable field (mid-femur). Abdominal ultrasound revealed thickened small intestinal loops and enlarged mesenteric lymph nodes. Cytology of the small intestine was suggestive of lymphosarcoma. T-cell lymphosarcoma of the sciatic nerve and small intestines was confirmed with incisional biopsy. Treatment consisted of systemic chemotherapy with vincristine followed by the Wisconsin-Madison feline lymphosarcoma protocol, but despite treatment the patient neurologically worsened and was euthanized after 54 days. Relevance and Novel Information: We present herein one of the first descriptions of neurolymphomatosis in the domestic cat that included post-intravenous contrast MRI. Treatment options based on recommendations for people with neurolymphomatosis include systemic chemotherapy, intrathecal chemotherapy and/or localized radiation chemotherapy. The authors recommend that all cats be screened for concurrent non-neuronal areas of lymphosarcoma before undergoing treatment for neurolymphomatosis, regardless of clinical signs. Competing Interests: Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu