Evolution of neuronal types and families.

Autor: Arendt D; Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany. Electronic address: arendt@embl.de., Bertucci PY; Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany., Achim K; Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany., Musser JM; Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012, Heidelberg, Germany.
Jazyk: angličtina
Zdroj: Current opinion in neurobiology [Curr Opin Neurobiol] 2019 Jun; Vol. 56, pp. 144-152. Date of Electronic Publication: 2019 Mar 01.
DOI: 10.1016/j.conb.2019.01.022
Abstrakt: Major questions in the evolution of neurons and nervous systems remain unsolved, such as the origin of the first neuron, the possible convergent evolution of neuronal phenotypes, and the transition from a relatively simple decentralized nerve net to the complex, centralized nervous systems found in modern bilaterian animals. In recent years, comparative single-cell transcriptomics has opened up new research avenues addressing these issues. Here, we review recent conceptual progress toward an evolutionary definition of cell types, and how it facilitates the identification and large-scale comparison of neuronal types and neuron type families from single-cell data - with the family of GABAergic neurons in distinct parts of the vertebrate forebrain as prime example. We also highlight strategies to infer cell type-specific innovation, so-called apomeres, from single-cell data.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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