Evolving Role of PET in Detecting and Characterizing Atherosclerosis.

Autor:	Høilund-Carlsen PF; Department of Nuclear Medicine, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3. salOdense C - DK-5000, Denmark. Electronic address: pfhc@rsyd.dk., Moghbel MC; Department of Radiology, Stanford University Medical Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5105, USA., Gerke O; Department of Nuclear Medicine, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark., Alavi A; Department of Radiology, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Jazyk:	angličtina
Zdroj:	PET clinics [PET Clin] 2019 Apr; Vol. 14 (2), pp. 197-209.
DOI:	10.1016/j.cpet.2018.12.001
Abstrakt:	Cardiovascular molecular imaging has focused on assessing myocardial perfusion and ventricular ejection fraction. These modalities target late downstream effects of the atherosclerotic disease process; this calls for a change of focus toward methods that can detect early arterial wall changes before macrocalcifications become visible on computed tomography angiography and provide a better understanding of the disease process. We summarize current knowledge on PET in atherosclerosis and highlight pertinent questions relating to the early detection of atherosclerosis. The future of PET in atherosclerosis may be early individualized quantification of the arteriosclerotic disease burden rather than exploration of features of individual arterial plaques. (Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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