Class I myosins: Highly versatile proteins with specific functions in the immune system.

Autor: Girón-Pérez DA; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México., Piedra-Quintero ZL; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México., Santos-Argumedo L; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
Jazyk: angličtina
Zdroj: Journal of leukocyte biology [J Leukoc Biol] 2019 May; Vol. 105 (5), pp. 973-981. Date of Electronic Publication: 2019 Mar 01.
DOI: 10.1002/JLB.1MR0918-350RRR
Abstrakt: Connections established between cytoskeleton and plasma membrane are essential in cellular processes such as cell migration, vesicular trafficking, and cytokinesis. Class I myosins are motor proteins linking the actin-cytoskeleton with membrane phospholipids. Previous studies have implicated these molecules in cell functions including endocytosis, exocytosis, release of extracellular vesicles and the regulation of cell shape and membrane elasticity. In immune cells, those proteins also are involved in the formation and maintenance of immunological synapse-related signaling. Thus, these proteins are master regulators of actin cytoskeleton dynamics in different scenarios. Although the localization of class I myosins has been described in vertebrates, their functions, regulation, and mechanical properties are not very well understood. In this review, we focused on and summarized the current understanding of class I myosins in vertebrates with particular emphasis in leukocytes.
(©2019 Society for Leukocyte Biology.)
Databáze: MEDLINE
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