Association of Complete Radiologic and Pathologic Response following Locoregional Therapy before Liver Transplantation with Long-Term Outcomes of Hepatocellular Carcinoma: A Retrospective Study.

Autor:	Habibollahi P; Penn Image Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Vascular and Interventional Radiology, University of Texas Southwestern Medical Center, Dallas, Texas., Shamchi SP; Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Choi JM; Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Gade TP; Penn Image Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Stavropoulos SW; Penn Image Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Hunt SJ; Penn Image Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Dagli M; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Sudheendra D; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Mondschein JI; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Soulen MC; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania., Nadolski GJ; Penn Image Guided Interventions Laboratory, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Vascular and Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: gregory.nadolski@uphs.upenn.edu.
Jazyk:	angličtina
Zdroj:	Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2019 Mar; Vol. 30 (3), pp. 323-329.
DOI:	10.1016/j.jvir.2018.11.037
Abstrakt:	Purpose: To evaluate long-term outcomes of patients with hepatocellular carcinoma (HCC) who show a complete response (CR) vs non-CR on pretransplantation imaging studies or pathologic evaluation of liver explants after locoregional therapy (LRT) before liver transplantation. Materials and Methods: Patients listed for liver transplantation for HCC (March 1998 to December 2010) undergoing LRT with available multiphase MR/CT imaging before transplantation were included. Pathologic response was evaluated based on liver explant pathology. A total of 108 patients (17 women; 16%) met the inclusion criteria. Results: Radiologic CR was achieved in 65 patients (60%) vs non-CR in 43 (40%), and pathologic CR was achieved in 36 patients (33%) vs non-CR in 72 (67%). Mean 5-year overall survival (OS) from the time of listing and recurrence-free survival (RFS) after liver transplantation were significantly better for patients with pathologic CR vs non-CR on explant pathology (OS, 83.3% vs 65.2% [28% difference; P = .046]; RFS, 80.6% vs 62.5% [29% difference; P = .045]). Mean 5-y OS and RFS were not significantly different between patients with radiologic CR or non-CR on pretransplantation imaging (OS, 75.4% vs 65.1% [P = .12]; RFS, 74% vs 62.8% [P = .17]). Conclusions: Achievement of a pathologic CR vs non-CR in response to LRT before liver transplantation for HCC is associated with improved OS from time of listing and improved RFS after liver transplantation. However, current imaging paradigms fall short of accurate delineation of response to LRT, resulting in poor correlation of outcomes between pathologic and radiologic CR. (Copyright © 2018 SIR. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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