Factors associated with relapses among patients treated for acute urticaria.

Autor: Maillet F; AP-HP, Urgences, Centre de Référence sur les Angiœdèmes à kinines (CRéAk), Hôpital Louis Mourier, Université Paris 7, Colombes, France., Wolff D; AP-HP, Urgences, Centre de Référence sur les Angiœdèmes à kinines (CRéAk), Hôpital Louis Mourier, Université Paris 7, Colombes, France., Soria A; AP-HP, Dermatologie, Groupe Urticaire de la Société Française de Dermatologie (GUS), Hôpital Tenon, Université Paris 6, Paris, France., Adnet F; AP-HP, Urgences - Samu 93, Hôpital Avicenne, Université Paris 13, Inserm U942, Bobigny, France., Panayotopoulos V; AP-HP, Médecine Interne, DHUi2B, Centre de Référence Associé sur les Angiœdèmes à Kinines (CRéAk), Hôpital Saint-Antoine, Université Paris 6, Paris, France., Gobert D; AP-HP, Médecine Interne, DHUi2B, Centre de Référence Associé sur les Angiœdèmes à Kinines (CRéAk), Hôpital Saint-Antoine, Université Paris 6, Paris, France., Lapostolle F; AP-HP, Urgences - Samu 93, Hôpital Avicenne, Université Paris 13, Inserm U942, Bobigny, France., Reuter PG; AP-HP, SAMU 92, Hôpital Raymond Poincaré, Université Paris Ile de France Ouest, Garches, France., Ghazali A; AP-HP, Urgences, Hôpital Bichat, Université Paris 7, Paris, France., Caux F; AP-HP, Dermatologie, Hôpital Avicenne, Université Paris 13, Inserm UMR1125, Bobigny, France., Fain O; AP-HP, Médecine Interne, DHUi2B, Centre de Référence Associé sur les Angiœdèmes à Kinines (CRéAk), Hôpital Saint-Antoine, Université Paris 6, Paris, France., Javaud N; AP-HP, Urgences, Centre de Référence sur les Angiœdèmes à kinines (CRéAk), Hôpital Louis Mourier, Université Paris 7, Colombes, France.
Jazyk: angličtina
Zdroj: The Journal of dermatology [J Dermatol] 2019 May; Vol. 46 (5), pp. 383-388. Date of Electronic Publication: 2019 Feb 28.
DOI: 10.1111/1346-8138.14830
Abstrakt: The benefit of corticosteroids in acute urticaria is controversial. Our objective was to determine the factors associated with relapses in patients presenting with acute urticaria. A retrospective observational study, including all patients with acute urticaria who visited the angioedema reference center of Academic Public Hospitals - Saint-Antoine in Paris between January 2015 and June 2017, was conducted. The study inclusion criterion was a diagnosis of acute urticaria in an adult patient. The urticaria was spontaneous or inducible urticaria. The primary outcome was relapse at day 7 and the secondary outcome was relapse at week 6. A total of 184 patients with a first episode of acute urticaria were included. Most of the patients were female (66%) with a mean age of 42 ± 16 years. Corticosteroid administration for treatment of acute urticaria was used in 102 (55%) patients. Overall, 85 (46%) patients had relapses after less than 7 days whereas 168 (91%) patients had relapses after more than 6 weeks. In univariate analysis, the rate of corticosteroid administration was significantly higher in cases of relapse after less than 7 days. No difference in relapse rates after more than 6 weeks appeared. In the multivariate analysis, the independent factor associated with relapses after less than 7 days was the administration of corticosteroids as treatment of acute urticaria (odds ratio, 1.93; 95% confidence interval, 1.06-3.57; P = 0.03). The prevalence of corticosteroid administration for patients with acute urticaria was high. Corticosteroid administration was an independent risk factor associated with relapses after less than 7 days.
(© 2019 Japanese Dermatological Association.)
Databáze: MEDLINE
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