[Interaction of prostacyclin synthase with cytochromes P450].

Autor: Gnedenko OV; Institute of Biomedical Chemistry, Moscow, Russia., Yablokov EO; Institute of Biomedical Chemistry, Moscow, Russia., Ershov PV; Institute of Biomedical Chemistry, Moscow, Russia., Svirid AV; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Shkel TV; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Haidukevich IV; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Strushkevich NV; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Gilep AA; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Usanov SA; Institute of Bioorganic Chemistry National Academy of Science of Belarus, Minsk, Belarus., Ivanov AS; Institute of Biomedical Chemistry, Moscow, Russia.
Jazyk: ruština
Zdroj: Biomeditsinskaia khimiia [Biomed Khim] 2019 Jan; Vol. 65 (1), pp. 63-66.
DOI: 10.18097/PBMC20196501063
Abstrakt: Biosensor experiments on investigation of interaction between prostacyclin synthase (PGIS) and different proteins of the cytochrome P450 monooxygenase systems were perfomed. Interaction of PGIS with microsomal (CYP21A2, CYP2E1) and mitochondrial (CYP27A1, CYP11B1, CYP11B2, CYP11A1) cytochrome P450s was detected. Kinetic and equilibrium parameters of protein complexes formation were determined. Data obtained suggest an essential role of these hemoproteins interaction in regulation of prostacyclin and thromboxane A2 biosynthesis.
Databáze: MEDLINE