Increased CMV IgG Antibody Titer is Associated with Non-AIDS Events among Virologically Suppressed HIV-Positive Persons.

Autor:	Hodowanec AC; Division of Infectious Diseases; Rush University Medical Center; Chicago Illinois., Lurain NS; Department of Immunology/Microbiology; Rush University Medical Center; Chicago Illinois., Krishnan S; Center for Biostatistics in AIDS Research; Harvard TH Chan School of Public Health; Boston Massachusetts., Bosch RJ; Center for Biostatistics in AIDS Research; Harvard TH Chan School of Public Health; Boston Massachusetts., Landay AL; Department of Immunology/Microbiology; Rush University Medical Center; Chicago Illinois.
Jazyk:	angličtina
Zdroj:	Pathogens & immunity [Pathog Immun] 2019; Vol. 4 (1), pp. 66-78. Date of Electronic Publication: 2019 Feb 14.
DOI:	10.20411/pai.v4i1.255
Abstrakt:	Background: Among HIV-positive individuals, increased levels of inflammation and immune activation persist even in the setting of effective antiretroviral therapy (ART) and are associated with greater rates of non-AIDS events. The etiology of this persistent inflammation is incompletely understood. Methods: Using a well-characterized cohort of 322 HIV-infected individuals on suppressive ART, we conducted a case-control study. Cytomegalovirus (CMV) immunoglobulin G (IgG) levels, plasma biomarkers, and T-cell phenotypes were measured/characterized from samples collected 1 year after ART initiation. Conditional logistic regression for matched case-control studies analyzed the associations of year 1 CMV-specific IgG level with the subsequent occurrence of any non-AIDS event. Correlations between continuous CMV IgG antibody levels and soluble and cellular markers were assessed. Results: We found that higher levels of CMV IgG were associated with increased risk of non-AIDS events (OR = 1.58 per IQR [95% CI: 1.12, 2.24], P = 0.01) and with elevated soluble and cellular markers of inflammation. Conclusions: The magnitude of the host immune response to CMV may play a role in the persistent inflammation and resultant morbid events observed in the HIV-positive population. Competing Interests: CONFLICTS OF INTEREST None of the authors have a commercial association that might pose a conflict of interest. Dr. Alan Landay is an associate editor for Pathogens and Immunity.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu