Ginsenosides from Korean red ginseng modulate T cell function via the regulation of NF-AT-mediated IL-2 production.

Autor: Vinh LB; 1College of Pharmacy, Chungnam National University, Daejeon, 34134 Republic of Korea.; 2Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam., Park JU; 3College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, 500-757 Republic of Korea., Duy LX; 1College of Pharmacy, Chungnam National University, Daejeon, 34134 Republic of Korea.; 4Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam., Nguyet NTM; 1College of Pharmacy, Chungnam National University, Daejeon, 34134 Republic of Korea., Yang SY; 1College of Pharmacy, Chungnam National University, Daejeon, 34134 Republic of Korea., Kim YR; 3College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, 500-757 Republic of Korea., Kim YH; 1College of Pharmacy, Chungnam National University, Daejeon, 34134 Republic of Korea.
Jazyk: angličtina
Zdroj: Food science and biotechnology [Food Sci Biotechnol] 2018 Jul 11; Vol. 28 (1), pp. 237-242. Date of Electronic Publication: 2018 Jul 11 (Print Publication: 2019).
DOI: 10.1007/s10068-018-0428-8
Abstrakt: Korean red ginseng is a traditional health food frequently used to prevent or treat various diseases worldwide. In this study, we evaluated the immunomodulatory activities of eleven compounds ( 1-11 ) isolated from Korean red ginseng, focusing on T cell function. First, the effects of the eleven compounds were studied on the regulation of IL-2, a potent T cell growth factor. Compounds 5 , 7 , and 9 significantly increased IL-2 secretion in phorbol 12-myristate 13-acetate (PMA)/ionomycin (Io)-induced EL-4 T cells. Next, we examined the effects of compounds 5 , 7 , and 9 on the regulation of transcription factors related to IL-2 production in T cells. Compound 9 significantly increased the PMA/Io-induced promoter activity of nuclear factor of activated T cells (NF-AT) in EL-4 T cells, but did not have any significant effects on the promoters of NF- κB. These results suggest that compound 9 activates T cell function via the regulation of NF-AT-mediated IL-2 production.
Competing Interests: Compliance with ethical standardsThe authors declare that they have no competing interests.
Databáze: MEDLINE
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