| Autor: |
Hu, Kuan H; Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. zhang.ming-rong@qst.go.jp., Hanyu M, Masayuki H, Xie L, Zhang Y, Nagatsu, Kotaro N, Suzuki, Hisashi S, Zhang MR |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Apr 04; Vol. 55 (29), pp. 4162-4165. |
| DOI: |
10.1039/c9cc00445a |
| Abstrakt: |
Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18F and 64Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized with acceptable radiochemical characteristics and their in vivo pharmacokinetics and PD-L1 imaging capability were systematically evaluated. This proof-of-principle study may provide new possibilities for PD-L1 PET imaging in cancers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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