C-F Bond Activation Mediated by Phosphorus Compounds.

Autor: Bayne JM; Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, M5S 3H6, Canada., Stephan DW; Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario, M5S 3H6, Canada.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Jul 17; Vol. 25 (40), pp. 9350-9357. Date of Electronic Publication: 2019 Mar 26.
DOI: 10.1002/chem.201900542
Abstrakt: The activation and functionalization of C-F bonds has garnered significant attention in the scientific community as a strategy to mitigate toxicity and environmental concerns, as well as provide new pathways to agro- and pharmaceutical chemicals and materials. Although several transition-metal-based systems have been developed for this transformation, the use of main-group compounds remains less explored. In recent years, several strategies for C-F bond activation have focused on the use of phosphorus-based reagents. In this Minireview, an overview of strategies is provided that exploits P V and P III -based Lewis acids as well as P III Lewis bases in frustrated Lewis pair (FLP) protocols for hydrodefluorination, C-C couplings and C-F derivatizations.
(© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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