Hepcidin cDNA evolution in vertebrates.
| Autor: | Boumaiza M; Laboratoire d'ingénierie des protéines et des molécules bioactives, Institut Nationale des Sciences Appliquées et de Technologie (I.N.S.A.T.), Tunis, Tunisie. Electronic address: m.boumaiza@yahoo.fr., Abidi S; Laboratoire de Biosurveillance de l'Environnement, Faculté des Sciences de Bizerte, Université Carthage, Zarzouna, Tunisie. |
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| Jazyk: | angličtina |
| Zdroj: | Vitamins and hormones [Vitam Horm] 2019; Vol. 110, pp. 1-16. Date of Electronic Publication: 2019 Feb 02. |
| DOI: | 10.1016/bs.vh.2019.01.001 |
| Abstrakt: | Hepcidin, belonging to the β-defensin family, was isolated for the first time from plasma and human urine. It is a cationic peptide, rich in cysteine bound with four disulfide bridges, which plays a major role in innate immunity and iron homeostasis. Some vertebrate species have multiple hepcidin homolog genes and each contains only one copy that functions as an iron regulator except hepcidin sequences in the pigeon (Columba livia). The aim of this chapter is to investigate the molecular evolution of several hepcidin gene from searches of the literature and public genomic databases from 17 different species, all among the vertebrates. (© 2019 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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