Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan.

Autor: Tan KY; Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Liew ST; Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Tan QY; Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Abdul-Rahman FN; Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Azmi NI; Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Sim SM; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Tan NH; Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Khomvilai S; Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama IV Road, Bangkok, Thailand., Sitprija V; Queen Saovabha Memorial Institute, Thai Red Cross Society, Rama IV Road, Bangkok, Thailand., Tan CH; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: tanch@um.edu.my.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2019 Mar 15; Vol. 160, pp. 55-58. Date of Electronic Publication: 2019 Feb 22.
DOI: 10.1016/j.toxicon.2019.02.010
Abstrakt: Gel filtration chromatography and gel electrophoresis revealed minimal protein degradation in lyophilized antivenoms which were 2-year expired (Hemato Polyvalent, Neuro Polyvalent; Thailand) and 18-year expired (Hemato Bivalent, Neuro Bivalent; Taiwan). All expired antivenoms retained immunological binding activity, and were able to neutralize the hemotoxic or neurotoxic as well as lethal effects of the homologous snake venoms. The findings show that antivenoms under proper storage conditions may remain relatively stable beyond the indicated shelf life.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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