L-arginine supplementation lowers blood pressure, protein excretion and plasma lipid profile in experimental salt-induced hypertension in pregnancy: Relevance to preeclampsia.

Autor: Arikawe AP; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. Electronic address: aarikawe@unilag.edu.ng., Udenze IC; Department of Clinical Pathology, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria., Olusanya AW; Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria., Akinnibosun OA; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria., Dike I; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria., Duru BN; Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: Pathophysiology : the official journal of the International Society for Pathophysiology [Pathophysiology] 2019 Sep - Dec; Vol. 26 (3-4), pp. 191-197. Date of Electronic Publication: 2019 Feb 13.
DOI: 10.1016/j.pathophys.2019.02.002
Abstrakt: This study aimed to investigate the effects of L-arginine supplementation on blood pressure, protein excretion, lipid profile in salt-induced hypertensive pregnant rats. Female Sprague-Dawley rats were divided into 4 groups. Control Preg (normal rat chow). Control Preg + L-ARG (normal rat chow and daily oral L-Arginine from 16th - 20th week). Salt Preg (high salt diet, 8%). Salt Preg + L-ARG (high salt diet, 8% and daily oral L-Arginine from 16th - 20th week. Non-invasive BP was recorded using a tail-cuff machine at 1 st and 2nd trimesters. On day 19 of pregnancy, invasive BP was obtained by carotid artery cannulation connected to LabChart-7 pro software. This was followed by blood samples collection for lipid profile analysis. L-arginine significantly reduced (P < 0.05) systolic, diastolic, MAP at 1 st, 2nd trimesters, day 19 of pregnancy, LDL, plasma and urinary creatinine and protein levels in Control Preg + L-ARG and Salt Preg + L-ARG groups compared to other groups. Urinary Na + and K + were significantly higher (P < 0.05) in Salt Preg + L-ARG group compared to other groups. Total cholesterol level was significantly higher (P < 0.05) in salt groups compared to control groups. Triglyceride level and urine volume were significantly higher (P < 0.05) in Salt Preg group compared to other groups. It also significantly increased (P < 0.05) HDL in Control Preg + L-ARG and Salt Preg + L-ARG groups compared to other groups. L-arginine supplementation ameliorates some deleterious effects in salt- induced hypertensive pregnant rats possibly through its known NO vasodilatory effect and might also mediate a diuretic like action.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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