Development, repair, and regeneration of the limb musculoskeletal system.

Autor:	Song JY; Program in Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI, United States., Pineault KM; Department of Cell & Regenerative Biology, University of Wisconsin, Madison, WI, United States., Wellik DM; Department of Cell & Regenerative Biology, University of Wisconsin, Madison, WI, United States. Electronic address: wellik@wisc.edu.
Jazyk:	angličtina
Zdroj:	Current topics in developmental biology [Curr Top Dev Biol] 2019; Vol. 132, pp. 451-486. Date of Electronic Publication: 2019 Jan 11.
DOI:	10.1016/bs.ctdb.2018.12.011
Abstrakt:	The limb musculoskeletal system provides a primary means for locomotion, manipulation of objects and protection for most vertebrate organisms. Intricate integration of the bone, tendon and muscle tissues are required for function. These three tissues arise largely independent of one another, but the connections formed during later development are maintained throughout life and are re-established following injury. Each of these tissues also have mesenchymal stem/progenitor cells that function in maintenance and repair. Here in, we will review the major events in the development of limb skeleton, tendon, and muscle tissues, their response to injury, and discuss current knowledge regarding resident progenitor/stem cells within each tissue that participate in development, repair, and regeneration in vivo. (© 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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