Elementary response triggered by transducin in retinal rods.
Autor: | Yue WWS; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Silverman D; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Ren X; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Frederiksen R; Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118., Sakai K; Department of Biophysics, Kyoto University, Kyoto 606-8502, Japan., Yamashita T; Department of Biophysics, Kyoto University, Kyoto 606-8502, Japan., Shichida Y; Department of Biophysics, Kyoto University, Kyoto 606-8502, Japan.; Research Organization for Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan., Cornwall MC; Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118., Chen J; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089., Yau KW; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; kwyau@jhmi.edu.; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205. |
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Jazyk: | angličtina |
Zdroj: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 12; Vol. 116 (11), pp. 5144-5153. Date of Electronic Publication: 2019 Feb 22. |
DOI: | 10.1073/pnas.1817781116 |
Abstrakt: | G protein-coupled receptor (GPCR) signaling is crucial for many physiological processes. A signature of such pathways is high amplification, a concept originating from retinal rod phototransduction, whereby one photoactivated rhodopsin molecule (Rho*) was long reported to activate several hundred transducins (G Competing Interests: The authors declare no conflict of interest. |
Databáze: | MEDLINE |
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