Individual- versus group-optimality in the production of secreted bacterial compounds.

Autor: Schiessl KT; Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, 8600, Switzerland.; Department of Environmental Systems Science, Swiss Federal Institute of Technology (ETH Zurich), Zürich, 8092, Switzerland.; Current Address: Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, 10027, New York., Ross-Gillespie A; Department of Plant and Microbial Biology, University of Zürich, Zürich, 8057, Switzerland., Cornforth DM; School of Biological Sciences, Georgia Institute of Technology, Atlanta, 30332, Georgia., Weigert M; Department of Plant and Microbial Biology, University of Zürich, Zürich, 8057, Switzerland., Bigosch C; Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH Zurich), Zürich, 8092, Switzerland., Brown SP; School of Biological Sciences, Georgia Institute of Technology, Atlanta, 30332, Georgia., Ackermann M; Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, 8600, Switzerland.; Department of Environmental Systems Science, Swiss Federal Institute of Technology (ETH Zurich), Zürich, 8092, Switzerland., Kümmerli R; Department of Plant and Microbial Biology, University of Zürich, Zürich, 8057, Switzerland.; Department of Quantitative Biomedicine, University of Zürich, Zürich, 8057, Switzerland.
Jazyk: angličtina
Zdroj: Evolution; international journal of organic evolution [Evolution] 2019 Apr; Vol. 73 (4), pp. 675-688. Date of Electronic Publication: 2019 Feb 28.
DOI: 10.1111/evo.13701
Abstrakt: How unicellular organisms optimize the production of compounds is a fundamental biological question. While it is typically thought that production is optimized at the individual-cell level, secreted compounds could also allow for optimization at the group level, leading to a division of labor where a subset of cells produces and shares the compound with everyone. Using mathematical modeling, we show that the evolution of such division of labor depends on the cost function of compound production. Specifically, for any trait with saturating benefits, linear costs promote the evolution of uniform production levels across cells. Conversely, production costs that diminish with higher output levels favor the evolution of specialization-especially when compound shareability is high. When experimentally testing these predictions with pyoverdine, a secreted iron-scavenging compound produced by Pseudomonas aeruginosa, we found linear costs and, consistent with our model, detected uniform pyoverdine production levels across cells. We conclude that for shared compounds with saturating benefits, the evolution of division of labor is facilitated by a diminishing cost function. More generally, we note that shifts in the level of selection from individuals to groups do not solely require cooperation, but critically depend on mechanistic factors, including the distribution of compound synthesis costs.
(© 2019 The Author(s). Evolution © 2019 The Society for the Study of Evolution.)
Databáze: MEDLINE
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