Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer.

Autor: Sato M; 1Graduate School of Health Science, Okayama University, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558 Japan., Miura K; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Kageyama C; 1Graduate School of Health Science, Okayama University, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558 Japan., Sakae H; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Obayashi Y; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Kawahara Y; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Matsushita O; 3Bacteriology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Yokota K; 1Graduate School of Health Science, Okayama University, 2-5-1 Shikata-cho Kita-ku, Okayama, 700-8558 Japan., Okada H; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Jazyk: angličtina
Zdroj: Infectious agents and cancer [Infect Agent Cancer] 2019 Feb 11; Vol. 14, pp. 4. Date of Electronic Publication: 2019 Feb 11 (Print Publication: 2019).
DOI: 10.1186/s13027-019-0221-1
Abstrakt: Background: Helicobacter pylori infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. The aim of the present study is to explore a biomarker for detecting people who has high risk of gastric cancer recurrence.
Methods: We analyzed the Interleukin-10 (IL-10) single nucleotide polymorphism (SNP) and IgG subclass responses to the bacteria in patients with early gastric cancer and recurrent gastric cancer.
Results: Patients with hetero-type in the 1082 SNP and CC genotype in the 592 SNP were at high risk of recurrence of gastric cancer. In patients with genotype carrying high risk of recurrence, IgG1 level tended to be higher than that in patients with other genotypes.
Conclusions: Dominance of T helper 2 (Th2) immunity controlled by IL-10 cytokine may be associated with H. pylori -associated gastric cancer recurrence.
Competing Interests: Ethical approval to carry out the study was obtained a priori from the Okayama University Ethics Committee (Number 2034). Written consent from the patient to participation this study was obtained.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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