Merkel Cell Polyomavirus Is Associated with Anal Infections in Men Who Have Sex with Men.

Autor:	Zanotta N; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34137 Trieste, Italy. zanottanunzia@gmail.com., Delbue S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milano, Italy. serena.delbue@unimi.it., Signorini L; Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milano, Italy. lucia.signorini@unimi.it., Villani S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milano, Italy. sonia.villani@unimi.it., D'Alessandro S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milano, Italy. sarah.dalessandro@unimi.it., Campisciano G; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34137 Trieste, Italy. giusi.campisciano@burlo.trieste.it., Colli C; MST Center, ASUITS, 34100 Trieste, Italy. claudia.colli@asuits.sanita.fvg.it., De Seta F; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34137 Trieste, Italy. Francesco.deseta@burlo.trieste.it., Ferrante P; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34137 Trieste, Italy. pasquale.ferrante@unimi.it., Comar M; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', 34137 Trieste, Italy. manola.comar@burlo.trieste.it.; Department of Medical Science, University of Trieste, 34127 Trieste, Italy. manola.comar@burlo.trieste.it.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2019 Feb 19; Vol. 7 (2). Date of Electronic Publication: 2019 Feb 19.
DOI:	10.3390/microorganisms7020054
Abstrakt:	Background: Viral infections of the anal/rectal tract of men who have sex with men (MSM) have been poorly studied. Methods: In total, 158 swab samples (81 anal/rectal, 65 throat/oral and 12 urethral) were collected from 126 MSM. DNA was isolated and subjected to real-time PCR assays for the detection of the sexually transmitted (ST) pathogens Chlamydia trachomatis , Neisseria gonorrhoeae and Mycoplasmas ssp , human papillomavirus (HPV) and six human polyomaviruses (HPyVs; JCPyV, BKPyV, Merkel cell PyV⁻MCPyV-, HPyV-6, HPyV-7 and HPyV-9). Results: C. trachomatis (31/126, 24.6%) and M. genitalium (30/126, 23.8%) were the most frequently detected ST pathogens. Thirty-one/126 (24.6%) patients were positive for at least one HPyV. The significantly ( p < 0.05) prevalent HPyV in the anal tract was MCPyV, which was amplified in 27/81 (33.3%) samples, followed by HPyV-6, which was amplified in 6/81 (7.4%) swabs. Coinfections with MCPyV and C. trachomatis or Mycoplasmas were found in 4/21 (19.0%) and 5/21 (23.8%) anal/rectal swabs, respectively. Three/4 MCPyV- C. trachomatis coinfected patients were symptomatic. Conclusions: Based on the high prevalence of MCPyV in the anal/rectal swabs from MSM patients and on the well-known oncogenic properties of MCPyV, sexual transmission and possible involvement of HPyVs in the pathogenesis of diseases of the anal canal should be further studied.
Databáze:	MEDLINE
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