Analysis of Anti-Glycan IgG and IgM Antibodies in Colorectal Cancer.

Autor: Tikhonov AA; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. alex.tihonoff@gmail.com., Savvateeva EN; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Chernichenko MA; P. A. Hertsen Moscow Research Oncological Institute, Affiliated Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, Russia., Maslennikov VV; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Sidorov DV; P. A. Hertsen Moscow Research Oncological Institute, Affiliated Branch of National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Moscow, Russia., Rubina AY; V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Kushlinskii NE; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Feb; Vol. 166 (4), pp. 489-493. Date of Electronic Publication: 2019 Feb 20.
DOI: 10.1007/s10517-019-04379-2
Abstrakt: We propose an approach that allows simultaneous determination of the levels of M and G isotypes of antibodies to the panel of glycans using microarrays. The level of IgG antibodies to 3'-O-su-Le a glycan detects patients with colorectal cancer with a sensitivity of 69.77% and specificity of 62.75%. The percentage of correctly classified colorectal cancer patients with the use of a combination of two markers IgM antibodies to glycans 3'-sialyl-TF and 3'-O-su-Le a is as high as 74.23%. The levels of IgM antibodies to 3'-O-su-Le a glycan differ significantly in patients with and without regional metastases. The levels of some of antiglycan IgM or IgG antibodies differed significantly in patients with tumors of different location and differentiation.
Databáze: MEDLINE