Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study.

Autor:	Kerber R; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Lorenz E; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; German Center for Infection Research, Braunschweig., Duraffour S; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Sissoko D; INSERM U1219, Bordeaux University, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France., Rudolf M; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Jaeger A; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; German Center for Infection Research, Braunschweig., Cisse SD; Ministry of Health Guinea, Guinea., Camara AM; Ministry of Health Guinea, Guinea., Miranda O; Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba., Castro CM; Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba., Akoi Bore J; European Mobile Laboratory Consortium, Hamburg.; Ministry of Health Guinea, Guinea., Raymond Koundouno F; European Mobile Laboratory Consortium, Hamburg.; Ministry of Health Guinea, Guinea., Repits J; European Mobile Laboratory Consortium, Hamburg.; Janssen-Cilag, Sollentuna, Sweden., Afrough B; European Mobile Laboratory Consortium, Hamburg.; Public Health England, Porton Down., Becker-Ziaja B; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Hinzmann J; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Mertens M; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig.; Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Greifswald., Vitoriano I; European Mobile Laboratory Consortium, Hamburg.; Public Health England, Porton Down., Hugh Logue C; European Mobile Laboratory Consortium, Hamburg.; Public Health England, Porton Down., Böttcher JP; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Pallasch E; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Sachse A; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Bah A; European Mobile Laboratory Consortium, Hamburg.; Swiss Tropical and Public Health Institute, Basel., Cabeza-Cabrerizo M; European Mobile Laboratory Consortium, Hamburg., Nitzsche K; European Mobile Laboratory Consortium, Hamburg., Kuisma E; European Mobile Laboratory Consortium, Hamburg.; Public Health England, Porton Down., Michel J; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Holm T; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Zekeng EG; European Mobile Laboratory Consortium, Hamburg., Cowley LA; European Mobile Laboratory Consortium, Hamburg.; Public Health England, London.; Milner Centre for Evolution, University of Bath, Bath., Garcia-Dorival I; European Mobile Laboratory Consortium, Hamburg.; Institute of Infection and Global Health, University of Liverpool, Liverpool., Hetzelt N; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Baum JHJ; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg., Portmann J; European Mobile Laboratory Consortium, Hamburg.; Federal Office for Civil Protection, Spiez Laboratory, Spiez., Carter L; European Mobile Laboratory Consortium, Hamburg.; University College London, London.; World Health Organization, Geneva, Switzerland., Yenamaberhan RL; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg., Camino A; European Mobile Laboratory Consortium, Hamburg., Enkirch T; European Mobile Laboratory Consortium, Hamburg.; Division of Veterinary Medicine, Paul-Ehrlich-Institut, Langen, Germany., Singethan K; European Mobile Laboratory Consortium, Hamburg.; Institute of Virology, Technische Universität München, Munich, Germany., Meisel S; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg., Mazzarelli A; European Mobile Laboratory Consortium, Hamburg.; National Institute for Infectious Diseases 'Lazzaro Spallanzani,' Rome, Italy., Kosgei A; European Mobile Laboratory Consortium, Hamburg.; Kenya Medical Research Institute, Nairobi, Kenya., Kafetzopoulou L; European Mobile Laboratory Consortium, Hamburg.; KU Leuven-University of Leuven, Rega Institute for Medical Research, Leuven, Belgium., Rickett NY; European Mobile Laboratory Consortium, Hamburg.; Institute of Infection and Global Health, University of Liverpool, Liverpool., Patrono LV; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg., Ghebreghiorghis L; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Arnold U; European Mobile Laboratory Consortium, Hamburg.; Robert Koch Institute, Berlin., Colin G; INSERM U1219, Bordeaux University, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France.; PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire., Juchet S; INSERM U1219, Bordeaux University, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France.; PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire., Marchal CL; INSERM U1219, Bordeaux University, Bordeaux, France., Kolie JS; Centre de Recherche en Santé Rurale, Maférinya, Guinea., Beavogui AH; Centre de Recherche en Santé Rurale, Maférinya, Guinea., Wurr S; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Bockholt S; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Krumkamp R; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; German Center for Infection Research, Braunschweig., May J; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; German Center for Infection Research, Braunschweig., Stoecker K; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig.; Bundeswehr Institute of Microbiology, Munich, Germany., Fleischmann E; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig.; Bundeswehr Institute of Microbiology, Munich, Germany., Ippolito G; European Mobile Laboratory Consortium, Hamburg.; National Institute for Infectious Diseases 'Lazzaro Spallanzani,' Rome, Italy., Carroll MW; European Mobile Laboratory Consortium, Hamburg.; Public Health England, Porton Down.; University of Southampton, South General Hospital, Southampton, United Kingdom., Koivogui L; Institut National de Santé Publique, Guinea., Magassouba N; Laboratoire des Fièvres Hémorragiques en Guinée, Université Gamal Abdel Nasser de Conakry, Guinea., Keita S; Ministry of Health Guinea, Guinea., Gurry C; World Health Organization, Geneva, Switzerland., Drury P; World Health Organization, Geneva, Switzerland., Diallo B; World Health Organization, Conakry, Guinea., Formenty P; World Health Organization, Geneva, Switzerland., Wölfel R; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig.; Bundeswehr Institute of Microbiology, Munich, Germany., Di Caro A; European Mobile Laboratory Consortium, Hamburg.; National Institute for Infectious Diseases 'Lazzaro Spallanzani,' Rome, Italy., Gabriel M; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig., Anglaret X; INSERM U1219, Bordeaux University, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France.; PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, Côte d'Ivoire., Malvy D; INSERM U1219, Bordeaux University, Bordeaux, France.; Bordeaux University Hospital, Bordeaux, France., Günther S; Bernhard Nocht Institute for Tropical Medicine, Hamburg.; European Mobile Laboratory Consortium, Hamburg.; German Center for Infection Research, Braunschweig.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2019 Jun 19; Vol. 220 (2), pp. 195-202.
DOI:	10.1093/infdis/jiz078
Abstrakt:	Background: In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus-specific reverse transcription-polymerase chain reaction assay and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to patients with EVD on a compassionate-use basis. Methods: To reduce biases in the raw field data, we carefully selected 163 of 286 patients with EVD for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry findings, favipiravir treatment, and outcome. Results: The case-fatality rate in favipiravir-treated patients was lower than in untreated patients (42.5% [31 of 73] vs 57.8% [52 of 90]; P = .053 by univariate analysis). In multivariate regression analysis, a higher Ct and a younger age were associated with survival (P < .001), while favipiravir treatment showed no statistically significant effect (P = .11). However, Kaplan-Meier analysis indicated a longer survival time in the favipiravir-treated group (P = .015). The study also showed characteristic changes in blood chemistry findings in patients who died, compared with survivors. Conclusions: Consistent with the JIKI trial, this retrospective study revealed a trend toward improved survival in favipiravir- treated patients; however, the effect of treatment was not statistically significant, except for its influence on survival time. (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
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