Volumetric and Shape Analysis of the Subcortical Regions in Schizophrenia Patients: A Pilot Study.

Autor: Jamea AA; Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alblowi M; Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Alghamdi J; Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Alosaimi FD; Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Al-Bader F; Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Bashir S; Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia.
Jazyk: angličtina
Zdroj: Journal of clinical imaging science [J Clin Imaging Sci] 2019 Jan 31; Vol. 9, pp. 1. Date of Electronic Publication: 2019 Jan 31 (Print Publication: 2019).
DOI: 10.4103/jcis.JCIS_61_18
Abstrakt: Objective: Investigation of brain structure in disease has been enhanced by developments in shape analysis methods that can identify subtle regional surface distortions. High-resolution magnetic resonance (MR) imaging was used to compare volumetric and shape analysis in schizophrenia (SCZ) patients and healthy controls (CON).
Methods: T1-weighted, 1-mm thick MR images were acquired for 15 patients with SCZ and 15 age-matched healthy controls using subcortical volume and shape analysis, which we believe to be complimentary to volumetric measures.
Results: SCZ patients showed significant shape differences compared to healthy controls in the right hippocampus ( P < 0.005), left and right putamen ( P < 0.044 and P < 0.031), left caudate ( P < 0.029), right pallidum ( P < 0.019), and left thalamus ( P < 0.033).
Conclusion: Our results provide evidence for subcortical neuroanatomical changes in patients with SCZ. Hence, shape analysis may aid in the identification of structural biomarkers for identifying individuals of SCZ.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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