Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice.

Autor:	Fulton AJ; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., Lamarca A; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom. angela.lamarca@christie.nhs.uk., Nuttall C; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., McCallum L; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., Pihlak R; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., O'Reilly D; Hepato-pancreato-biliary Surgical Department, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, United Kingdom., Lalloo F; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary's Hospital, Manchester M13 9WL, United Kingdom., McNamara MG; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., Hubner RA; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom., Clancy T; Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary's Hospital, Manchester M13 9WL, United Kingdom., Valle JW; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal oncology [World J Gastrointest Oncol] 2019 Feb 15; Vol. 11 (2), pp. 102-116.
DOI:	10.4251/wjgo.v11.i2.102
Abstrakt:	Background: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. Aim: To assess the referral pathways for genetic consultations in PDAC. Methods: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. Results: Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. Conclusion: Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments. Competing Interests: Conflict-of-interest statement: Authors have no conflict of interest to declare related to this work.
Databáze:	MEDLINE
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