Genome-wide association study of germline variants and breast cancer-specific mortality.

Autor:	Escala-Garcia M; The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands., Guo Q; University of Cambridge, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Cambridge, UK. qg209@medschl.cam.ac.uk., Dörk T; Hannover Medical School, Gynaecology Research Unit, Hannover, Germany., Canisius S; The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.; The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Carcinogenesis, Amsterdam, The Netherlands., Keeman R; The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands., Dennis J; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK., Beesley J; QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia., Lecarpentier J; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK., Bolla MK; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK., Wang Q; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK., Abraham J; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.; Cambridge Experimental Cancer Medicine Centre, Cambridge, UK.; University of Cambridge NHS Foundation Hospitals, Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Andrulis IL; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada.; University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada., Anton-Culver H; University of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA, USA., Arndt V; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany., Auer PL; Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA.; University of Wisconsin-Milwaukee, Zilber School of Public Health, Milwaukee, WI, USA., Beckmann MW; University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany., Behrens S; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Benitez J; Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain.; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain., Bermisheva M; Ufa Scientific Center of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia., Bernstein L; Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA., Blomqvist C; University of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, Finland.; Örebro University Hospital, Department of Oncology, Örebro, Sweden., Boeckx B; VIB, VIB Center for Cancer Biology, Leuven, Belgium.; University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Bojesen SE; Copenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.; Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark., Bonanni B; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS Milan, Milan, 20141, Italy., Børresen-Dale AL; Oslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway.; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway.; Department of Research, Vestre Viken Hospital, Drammen, Norway; Section for Breast- and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Ullevål, Oslo, Norway.; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.; Department of Pathology at Akershus University hospital, Lørenskog, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Division of Surgery and Cancer and Transplantation Medicine, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.; National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Breast Cancer Research Consortium, Oslo University Hospital, Oslo, Norway., Brauch H; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Brenner H; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Division of Preventive Oncology, Heidelberg, Germany., Brentnall A; Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, London, UK., Brinton L; National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA., Broberg P; Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden., Brock IW; University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield, UK., Brucker SY; University of Tübingen, Department of Gynecology and Obstetrics, Tübingen, Germany., Burwinkel B; University of Heidelberg, Department of Obstetrics and Gynecology, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, Germany., Caldas C; Cambridge Experimental Cancer Medicine Centre, Cambridge, UK.; University of Cambridge NHS Foundation Hospitals, Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; The Institute of Cancer Research, Section of Cancer Genetics, London, UK., Caldés T; Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain., Campa D; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.; University of Pisa, Department of Biology, Pisa, Italy., Canzian F; German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, Germany., Carracedo A; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Genomic Medicine Group, Galician Foundation of Genomic Medicine, SERGAS, Santiago de Compostela, Spain.; Universidad de Santiago de Compostela, Centro de Investigación en Red de Enfermedades Raras (CIBERER), Santiago De Compostela, Spain.; King Abdulaziz University, Center of Excellence in Genomic Medicine, Jeddah, Kingdom of Saudi Arabia., Carter BD; American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA., Castelao JE; Instituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, Spain., Chang-Claude J; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.; University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany., Chanock SJ; National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA., Chenevix-Trench G; QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia., Cheng TD; Roswell Park Cancer Institute, Division of Cancer Prevention and Control, Buffalo, NY, USA., Chin SF; University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK., Clarke CL; University of Sydney, Westmead Institute for Medical Research, Sydney, NSW, Australia., Cordina-Duverger E; INSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France., Couch FJ; Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA., Cox DG; Imperial College London, Department of Epidemiology and Biostatistics, School of Public Health, London, UK.; Cancer Research Center of Lyon, INSERM U1052, Lyon, France., Cox A; University of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield, UK., Cross SS; University of Sheffield, Academic Unit of Pathology, Department of Neuroscience, Sheffield, UK., Czene K; Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden., Daly MB; Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA., Devilee P; Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands.; Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands., Dunn JA; University of Warwick, Warwick Clinical Trials Unit, Coventry, UK., Dunning AM; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK., Durcan L; University of Southampton, Southampton Clinical Trials Unit, Faculty of Medicine, Southampton, UK.; University of Southampton, Cancer Sciences Academic Unit, Faculty of Medicine, Southampton, UK., Dwek M; University of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK., Earl HM; University of Cambridge NHS Foundation Hospitals, Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; University of Cambridge, Department of Oncology, Cambridge, UK., Ekici AB; Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, Germany., Eliassen AH; Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA., Ellberg C; Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden., Engel C; University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.; University of Leipzig, LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig, Germany., Eriksson M; Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden., Evans DG; University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.; St Marys Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK., Figueroa J; National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.; The University of Edinburgh Medical School, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Edinburgh, UK., Flesch-Janys D; University Medical Centre Hamburg-Eppendorf, Institute for Medical Biometrics and Epidemiology, Hamburg, Germany.; University Medical Centre Hamburg-Eppendorf, Department of Cancer Epidemiology, Clinical Cancer Registry, Hamburg, Germany., Flyger H; Copenhagen University Hospital, Department of Breast Surgery, Herlev and Gentofte Hospital, Herlev, Denmark., Gabrielson M; Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden., Gago-Dominguez M; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Genomic Medicine Group, Galician Foundation of Genomic Medicine, SERGAS, Santiago de Compostela, Spain.; University of California San Diego, Moores Cancer Center, La Jolla, CA, USA., Galle E; VIB, VIB Center for Cancer Biology, Leuven, Belgium.; University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Gapstur SM; American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA., García-Closas M; National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.; Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK., García-Sáenz JA; Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain., Gaudet MM; American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA., George A; The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.; The Royal Marsden NHS Foundation Trust, Cancer Genetics Unit, London, UK., Georgoulias V; University Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece., Giles GG; Cancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia.; Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, VIC, Australia., Glendon G; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada., Goldgar DE; Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT, USA., González-Neira A; Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain., Alnæs GIG; Oslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway., Grip M; University of Oulu, Department of Surgery, Oulu University Hospital, Oulu, Finland., Guénel P; INSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France., Haeberle L; Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Centre Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany., Hahnen E; University Hospital of Cologne, Centre for Hereditary Breast and Ovarian Cancer, Cologne, Germany.; University of Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany., Haiman CA; University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA., Håkansson N; Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden., Hall P; Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.; South General Hospital, Department of Oncology, Stockholm, Sweden., Hamann U; German Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany., Hankinson S; University of Massachusetts, Amherst, Department of Biostatistics & Epidemiology, Amherst, MA, USA., Harkness EF; University of Manchester, Manchester Academic Health Science Centre, Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.; Wythenshawe Hospital, Manchester University NHS Foundation Trust, Nightingale Breast Screening Centre, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Unit, Manchester, UK., Harrington PA; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK., Hart SN; Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA., Hartikainen JM; University of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.; University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland.; Kuopio University Hospital, Imaging Centre, Department of Clinical Pathology, Kuopio, Finland., Hein A; University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany., Hillemanns P; Hannover Medical School, Gynaecology Research Unit, Hannover, Germany., Hiller L; University of Warwick, Warwick Clinical Trials Unit, Coventry, UK., Holleczek B; Saarland Cancer Registry, Saarbruecken, Germany., Hollestelle A; Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands., Hooning MJ; Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands., Hoover RN; National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA., Hopper JL; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia., Howell A; University of Manchester, Institute of Cancer studies, Manchester, UK., Huang G; German Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany., Humphreys K; Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden., Hunter DJ; Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA, USA.; University of Oxford, Nuffield Department of Population Health, Oxford, UK., Janni W; Cancer Research UK Edinburgh Centre, Edinburgh, UK., John EM; Cancer Prevention Institute of California, Department of Epidemiology, Fremont, CA, USA.; Stanford University School of Medicine, Department of Health Research and Policy - Epidemiology, Stanford, CA, USA.; Stanford University School of Medicine, Department of Biomedical Data Science, Stanford, CA, USA., Jones ME; Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK., Jukkola-Vuorinen A; Tampere University Hospital, Department of Oncology, Tampere, Finland., Jung A; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Kaaks R; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany., Kabisch M; German Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany., Kaczmarek K; Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland., Kerin MJ; National University of Ireland, Surgery, School of Medicine, Galway, Ireland., Khan S; University of Helsinki, Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland., Khusnutdinova E; Ufa Scientific Center of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia.; Bashkir State University, Department of Genetics and Fundamental Medicine, Ufa, Russia., Kiiski JI; University of Helsinki, Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland., Kitahara CM; National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA., Knight JA; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Prosserman Centre for Population Health Research, Toronto, ON, Canada.; University of Toronto, Division of Epidemiology, Dalla Lana School of Public Health, Toronto, ON, Canada., Ko YD; Johanniter Krankenhaus, Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Bonn, Germany., Koppert LB; Erasmus MC Cancer Institute, Department of Surgical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands., Kosma VM; University of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.; University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland.; Kuopio University Hospital, Imaging Centre, Department of Clinical Pathology, Kuopio, Finland., Kraft P; Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA, USA., Kristensen VN; Oslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway.; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway.; Department of Research, Vestre Viken Hospital, Drammen, Norway; Section for Breast- and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Ullevål, Oslo, Norway.; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.; Department of Pathology at Akershus University hospital, Lørenskog, Norway.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Division of Surgery and Cancer and Transplantation Medicine, Oslo University Hospital-Radiumhospitalet, Oslo, Norway.; National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway.; Department of Oncology, Akershus University Hospital, Lørenskog, Norway.; Breast Cancer Research Consortium, Oslo University Hospital, Oslo, Norway., Krüger U; Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden., Kühl T; University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany., Lambrechts D; VIB, VIB Center for Cancer Biology, Leuven, Belgium.; University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven, Belgium., Le Marchand L; University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI, USA., Lee E; University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA., Lejbkowicz F; Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel., Li L; Tianjin Medical University Cancer Institute and Hospital, Department of Epidemiology, Tianjin, China., Lindblom A; Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden., Lindström S; University of Washington School of Public Health, Department of Epidemiology, Seattle, WA, USA.; Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA, USA., Linet M; National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA., Lissowska J; M. Sklodowska-Curie Cancer Centre, Oncology Institute, Department of Cancer Epidemiology and Prevention, Warsaw, Poland., Lo WY; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Loibl S; GmbH, German Breast Group, Neu Isenburg, Germany., Lubiński J; Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland., Lux MP; Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Centre Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany., MacInnis RJ; Cancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia., Maierthaler M; German Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, Germany., Maishman T; University of Southampton, Southampton Clinical Trials Unit, Faculty of Medicine, Southampton, UK.; University of Southampton, Cancer Sciences Academic Unit, Faculty of Medicine, Southampton, UK., Makalic E; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia., Mannermaa A; University of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.; University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio, Finland.; Kuopio University Hospital, Imaging Centre, Department of Clinical Pathology, Kuopio, Finland., Manoochehri M; German Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany., Manoukian S; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Medical Genetics, Department of Medical Oncology and Haematology, Milan, Italy., Margolin S; Karolinska Institutet, Department of Clinical Science and Education, Sšdersjukhuset, Stockholm, Sweden., Martinez ME; University of California San Diego, Moores Cancer Center, La Jolla, CA, USA.; University of California San Diego, Department of Family Medicine and Public Health, La Jolla, CA, USA., Mavroudis D; University Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece., McLean C; The Alfred Hospital, Anatomical Pathology, Melbourne, VIC, Australia., Meindl A; Ludwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany., Middha P; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.; University of Heidelberg, Faculty of Medicine, Heidelberg, Germany., Miller N; National University of Ireland, Surgery, School of Medicine, Galway, Ireland., Milne RL; Cancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia., Moreno F; Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain., Mulligan AM; University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada.; University Health Network, Laboratory Medicine Program, Toronto, ON, Canada., Mulot C; INSERM UMR-S1147, Université Paris Sorbonne Cité, Paris, France., Nassir R; University of California Davis, Department of Biochemistry and Molecular Medicine, Davis, CA, USA., Neuhausen SL; Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA., Newman WT; University of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.; St Marys Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK., Nielsen SF; Copenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.; Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark., Nordestgaard BG; Copenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.; Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark., Norman A; Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA., Olsson H; Lund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden., Orr N; Queen's University Belfast, Centre for Cancer Research and Cell Biology, Belfast, Ireland, UK., Pankratz VS; University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA., Park-Simon TW; Hannover Medical School, Gynaecology Research Unit, Hannover, Germany., Perez JIA; Hospital Monte Naranco, Servicio de Cirug'a General y Especialidades, Oviedo, Spain., Pérez-Barrios C; Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain., Peterlongo P; The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, IFOM, Milan, Italy., Petridis C; King's College London, Research Oncology, Guy's Hospital, London, UK., Pinchev M; Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel., Prajzendanc K; Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland., Prentice R; Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA., Presneau N; University of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK., Prokofieva D; Bashkir State University, Department of Genetics and Fundamental Medicine, Ufa, Russia., Pylkäs K; University of Oulu, Laboratory of Cancer Genetics and Tumour Biology, Cancer and Translational Medicine Research Unit, Biocentre Oulu, Oulu, Finland.; Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumour Biology, Oulu, Finland., Rack B; Ludwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany., Radice P; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy., Ramachandran D; Hannover Medical School, Gynaecology Research Unit, Hannover, Germany., Rennert G; Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel., Rennert HS; Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel., Rhenius V; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK., Romero A; Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain., Roylance R; UCLH Foundation Trust, Department of Oncology, London, UK., Saloustros E; University Hospital of Larissa, Department of Oncology, Larissa, Greece., Sawyer EJ; King's College London, Research Oncology, Guy's Hospital, London, UK., Schmidt DF; The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia., Schmutzler RK; University Hospital of Cologne, Centre for Hereditary Breast and Ovarian Cancer, Cologne, Germany.; University of Cologne, Centre for Molecular Medicine Cologne (CMMC), Cologne, Germany., Schneeweiss A; University of Heidelberg, Department of Obstetrics and Gynecology, Heidelberg, Germany.; University of Heidelberg, National Centre for Tumour Diseases, Heidelberg, Germany., Schoemaker MJ; The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK., Schumacher F; Case Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland, OH, USA., Schwentner L; Cancer Research UK Edinburgh Centre, Edinburgh, UK., Scott RJ; John Hunter Hospital, Division of Molecular Medicine, Pathology North, Newcastle, NSW, Australia.; University of Newcastle, Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, Callaghan, NSW, Australia.; John Hunter Hospital, Hunter Medical Research Institute, Newcastle, NSW, Australia.; University of Newcastle, Centre for Information Based Medicine, Callaghan, Newcastle, NSW, Australia., Scott C; Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA., Seynaeve C; Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands., Shah M; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK., Simard J; Centre Hospitalier Universitaire de Québec - Université Laval Research Centre, Genomics Centre, Québec City, QC, Canada., Smeets A; University Hospitals Leuven, Department of Surgical Oncology, Leuven, Belgium., Sohn C; University of Heidelberg, National Centre for Tumour Diseases, Heidelberg, Germany., Southey MC; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia.; The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia., Swerdlow AJ; The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.; The Institute of Cancer Research, Division of Breast Cancer Research, London, UK., Talhouk A; BC Cancer Agency and University of British Columbia, British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, Vancouver, BC, Canada.; University of British Columbia, Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada.; University of British Columbia, Department of Obstetrics and Gynaecology, Vancouver, BC, Canada., Tamimi RM; Harvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.; Harvard T.H. 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Jazyk:	angličtina
Zdroj:	British journal of cancer [Br J Cancer] 2019 Mar; Vol. 120 (6), pp. 647-657. Date of Electronic Publication: 2019 Feb 21.
DOI:	10.1038/s41416-019-0393-x
Abstrakt:	Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). Results: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10 -8 . For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10 -7 , hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10 -7 , HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. Conclusions: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.
Databáze:	MEDLINE
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