| Autor: |
Fouad TR; 1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt., Abdelsameea E; 1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt., Elsabaawy M; 1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt., Ashraf Eljaky M; 1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt., Zaki El-Shenawy S; 2 Clinical Biochemistry Department, National Liver Institute, Menofia University, Menofia Governate, Egypt., Omar N; 1 Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Menofia Governate, Egypt. |
| Abstrakt: |
Cirrhotic patients with ascites are at high risk of developing spontaneous bacterial peritonitis (SBP). After exclusion of patients with acute kidney injury (AKI) or other infections, urinary neutrophil gelatinase-associated lipocalin (NGAL) levels were compared between two matched groups of Egyptian cirrhotic patients with ascites, mostly secondary to hepatitis C infection (98%). Group 1 had SBP (n = 41) and group 2 did not (n = 45). By univariate analysis, urinary-NGAL, high total bilirubin, serum creatinine, international normalised ratio and the Model of End-Stage Liver Disease (MELD) score and low platelet count were all significantly correlated with the presence of SBP, but only urinary-NGAL could independently predict development of SBP ( P = 0.001). Urinary-NGAL at a cut-off value of 1225 pg/mL, showed a sensitivity of 95% and a specificity of 76%, and is therefore a most useful tool. |
