Volitional control of single-electrode high gamma local field potentials by people with paralysis.

Autor: Milekovic T; Department of Neuroscience, Brown University , Providence, Rhode Island.; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; Department of Fundamental Neuroscience, Faculty of Medicine, University of Geneva , Geneva , Switzerland., Bacher D; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; School of Engineering, Brown University , Providence, Rhode Island., Sarma AA; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; School of Engineering, Brown University , Providence, Rhode Island.; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development Service, Department of Veterans Affairs , Providence, Rhode Island., Simeral JD; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; School of Engineering, Brown University , Providence, Rhode Island.; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development Service, Department of Veterans Affairs , Providence, Rhode Island., Saab J; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; School of Engineering, Brown University , Providence, Rhode Island., Pandarinath C; Department of Neurosurgery, Stanford University , Stanford, California.; Department of Electrical Engineering, Stanford University , Stanford, California.; Stanford Neurosciences Institute, Stanford University , Stanford, California., Yvert B; Department of Neuroscience, Brown University , Providence, Rhode Island.; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; Inserm, University of Grenoble, Clinatec-Lab U1205, Grenoble , France., Sorice BL; Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts., Blabe C; Department of Neurosurgery, Stanford University , Stanford, California., Oakley EM; Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts., Tringale KR; Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts., Eskandar E; Department of Neurosurgery, Massachusetts General Hospital , Boston, Massachusetts.; Harvard Medical School , Boston, Massachusetts., Cash SS; Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts.; Harvard Medical School , Boston, Massachusetts., Shenoy KV; Department of Electrical Engineering, Stanford University , Stanford, California.; Stanford Neurosciences Institute, Stanford University , Stanford, California.; Neurosciences Program, Stanford University , Stanford, California.; Department of Neurobiology, Stanford University , Stanford, California.; Department of Bioengineering, Stanford University , Stanford, California., Henderson JM; Department of Neurosurgery, Stanford University , Stanford, California.; Stanford Neurosciences Institute, Stanford University , Stanford, California.; Department of Neurology and Neurological Sciences, Stanford University , Stanford, California., Hochberg LR; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; School of Engineering, Brown University , Providence, Rhode Island.; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development Service, Department of Veterans Affairs , Providence, Rhode Island.; Department of Neurology, Massachusetts General Hospital , Boston, Massachusetts.; Harvard Medical School , Boston, Massachusetts., Donoghue JP; Department of Neuroscience, Brown University , Providence, Rhode Island.; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development Service, Department of Veterans Affairs , Providence, Rhode Island.
Jazyk: angličtina
Zdroj: Journal of neurophysiology [J Neurophysiol] 2019 Apr 01; Vol. 121 (4), pp. 1428-1450. Date of Electronic Publication: 2019 Feb 20.
DOI: 10.1152/jn.00131.2018
Abstrakt: Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user's movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such "biomimetic" BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control. In contrast, a biofeedback approach may surpass these limitations by letting the participants generate new control signals and learn strategies that improve the volitional control of signals used for effector control. Here, we show that, by using a biofeedback paradigm, three individuals with tetraplegia achieved volitional control of gamma LFPs (40-400 Hz) recorded by a single microelectrode implanted in the precentral gyrus. Control was improved over a pair of consecutive sessions up to 3 days apart. In all but one session, the channel used to achieve control lacked distinguishable action potentials. Our results indicate that biofeedback LFP-based BCIs may potentially contribute to the neural modulation necessary to obtain reliable and useful control of effectors. NEW & NOTEWORTHY Our study demonstrates that people with tetraplegia can volitionally control individual high-gamma local-field potential (LFP) channels recorded from the motor cortex, and that this control can be improved using biofeedback. Motor cortical LFP signals are thought to be both informative and stable intracortical signals and, thus, of importance for future brain-computer interfaces.
Databáze: MEDLINE