SERUM CYTOKINE OF IL-2, IL-10 AND IL-12 LEVELS IN PATIENTS WITH STOMACH ADENOCARCINOMA.

Autor:	Shokrzadeh M; Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran., Mohammadpour A; Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran., Hoseini V; Mazandaran University of Medical Sciences, Gastrointestinal Cancer Research Center, Sari, Iran., Abediankenari S; Mazandaran University of Medical Sciences, Immunogenetics Research Center, Sari, Iran., Ghassemi-Barghi N; Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran., Tabari YS; Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran.
Jazyk:	angličtina
Zdroj:	Arquivos de gastroenterologia [Arq Gastroenterol] 2018 Oct-Dec; Vol. 55 (4), pp. 385-389.
DOI:	10.1590/S0004-2803.201800000-83
Abstrakt:	Background: Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide. Objective: We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer. Methods: We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. We measured serum IL-2, IL-10 and IL-12 Levels by a sandwich enzyme-linked immunosorbent assay using the IBL international GMBH kit. Results: The serum IL-10 levels in the patients with Gastric adenocarcinoma were significantly higher than those of the healthy controls (P=0.02). There were no significant differences in serum IL-2 and IL-12 levels between patients with gastric cancer and healthy controls. Conclusion: Increased levels of IL-10 might be useful as diagnostic biomarkers for Gastric adenocarcinoma; however, this needs to be confirmed with larger number of patients and with control groups other than blood donors, properly age paired. These results suggest that positive expression of IL-10 may be useful as a molecular marker to distinguish stage of gastric cancers which can be more readily controlled.
Databáze:	MEDLINE
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