In vitro activity of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Trichosporon asahii.

Autor: Felli Kubiça T; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.; Integrated Regional University of High Uruguay and Missions (URI), Santiago, Brazil., Bedin Denardi L; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.; Integrated Regional University of High Uruguay and Missions (URI), Santiago, Brazil., Silva de Loreto É; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Zeni G; Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Weiblen C; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Oliveira V; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Morais Santurio J; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Hartz Alves S; Department of Microbiology and Parasitology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
Jazyk: angličtina
Zdroj: Mycoses [Mycoses] 2019 May; Vol. 62 (5), pp. 428-433. Date of Electronic Publication: 2019 Mar 13.
DOI: 10.1111/myc.12906
Abstrakt: This study evaluated the in vitro susceptibility of Trichosporon asahii strains to diphenyl diselenide (DPDS) and ebselen (EBS) alone and in combination with amphotericin B (AMB), fluconazole (FCZ), itraconazole (ITZ) and caspofungin (CAS) using the microdilution method. EBS showed in vitro activity against T asahii strains with minimal inhibitory concentration (MIC) ranged from 0.25 to 8.0 μg/mL. For DPDS, the MIC ranged from 8.0 to 64 μg/mL. The combinations demonstrating the greatest synergism rate against fluconazole-resistant T asahii strains were the following: CAS + DPDS (96.67%), AMB + DPDS (93.33%), FCZ + DPDS (86.67%) and ITZ + DPDS (83.33%). The combinations AMB + DPDS and AMB + EBS exhibited the highest synergism rate against the fluconazole-susceptible (FS) T asahii strains (90%). Antagonism was observed in the following combinations: FCZ + EBS (80%) and FCZ + DPDS (13.33%) against the FS strains, and ITZ + EBS (20%) against the FR strains. Our findings suggest that the antimicrobial activity of DPDS and EBS against T. asahii and its use as an adjuvant therapy with antifungal agents warrant in vivo experimental investigation.
(© 2019 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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