| Autor: |
Alchinova IB; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia.; Research Institute for Space Medicine, Federal Research Center of Specialized Health Care and Medical Technologies, Federal Medical-Biological Agency, Ministry of Health of the Russian Federation, Moscow, Russia., Polyakova MV; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia. nedzumy@bk.ru., Yakovenko EN; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia., Medvedeva YS; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia., Saburina IN; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia.; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia., Karganov MY; Research Institute of General Pathology and Pathophysiology, Ministry of Health of the Russian Federation, Moscow, Russia. |
| Abstrakt: |
C57Bl/6J mice were exposed to γ-radiation in a dose of 7.5 Gy. A week later, the experimental group received intravenous injection of extracellular vesicles isolated from the culture medium of human bone marrow multipotent mesenchymal stromal cells. Changes in the physiological parameters of animals were assessed by laser correlation spectroscopy, histological examination, cytometry, and by differential leukocyte count. In 3 and 6 weeks, the parameters of the experimental group occupied an intermediate position between the intact and irradiated groups or did not differ significantly from the parameters of the intact group. The rate and efficiency of recovery varied at different levels of organization. Reduction of damage caused by irradiation in a sublethal dose at different levels of organization of experimental animals was shown. |
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