Combination of Mesenchymal Stromal Cells and Cardiac Stem Cells in a Multilayer Cell Construct Promotes Activation of Notch Signaling and Initiation of Endothelial Differentiation.

Autor: Shevchenko EK; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. dr.eshevchenko@gmail.com., Dergilev KV; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Tsokolaeva ZI; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Beloglazova IB; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Molokotina YD; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Parfenova EV; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia., Men'shikov MY; National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Feb; Vol. 166 (4), pp. 548-552. Date of Electronic Publication: 2019 Feb 19.
DOI: 10.1007/s10517-019-04390-7
Abstrakt: We showed the possibility of generating combined tissue-engineered cell consisting of layers of rat cardiac stem cells and mesenchymal stromal cells from the adipose tissue. Cell-cell interaction within the cell sheet promoted proliferation of cardiac stem cells, expression of endothelial differentiation marker ETS1, and Notch signaling activation. The obtained results provide new insights into possible mechanisms of stimulation of endogenous regeneration processes after myocardial damage and demonstrate potential of cell-based cardiomyoplasty with the use of these combined cell sheets.
Databáze: MEDLINE
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