Opportunities for antimicrobial stewardship in patients with acute bacterial skin and skin structure infections who are unsuitable for beta-lactam antibiotics: a multicenter prospective observational study.

Autor:	Sandoe JAT; Leeds Teaching Hospitals NHS Trust and University of Leeds, Leeds, UK., Saeed K; Hampshire Hospitals NHS Foundation Trust and University of Southampton, Southampton, UK., Guleri A; Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK., Hand KS; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Dillon R; Merck Sharp & Dohme UK Ltd. (MSD), Hoddesdon, UK., Allen M; Merck Sharp & Dohme UK Ltd. (MSD), Hoddesdon, UK., Mayes A; Merck Sharp & Dohme UK Ltd. (MSD), Hoddesdon, UK., Glen F; pH Associates Ltd, Marlow, UK., Gonzalez-Ruiz A; Darent Valley Hospital, Dartford and Gravesham NHS Trust, Dartford, UK.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in infectious disease [Ther Adv Infect Dis] 2019 Feb 04; Vol. 6, pp. 2049936118823655. Date of Electronic Publication: 2019 Feb 04 (Print Publication: 2019).
DOI:	10.1177/2049936118823655
Abstrakt:	Purpose: The objective of this prospective, observational study was to describe the treatment, severity assessment and healthcare resources required for management of patients with acute bacterial skin and skin structure infections who were unsuitable for beta-lactam antibiotic treatments. Methods: Patients were enrolled across five secondary care National Health Service hospitals. Eligible patients had a diagnosis of acute bacterial skin and skin structure infection and were considered unsuitable for beta-lactam antibiotics (e.g. confirmed/suspected methicillin-resistant Staphylococcus aureus , beta-lactam allergy). Data regarding diagnosis, severity of the infection, antibiotic treatment and patient management were collected. Results: 145 patients with acute bacterial skin and skin structure infection were included; 79% ( n = 115) patients received greater than two antibiotic regimens; median length of the first antibiotic regimen was 2 days (interquartile range of 1-5); median time to switch from intravenous to oral antibiotics was 4 days (interquartile range of 3-8, n = 72/107); 25% ( n = 10/40) patients with Eron class 1 infection had systemic inflammatory response syndrome, suggesting they were misclassified. A higher proportion of patients with systemic inflammatory response syndrome received treatment in an inpatient setting, and their length of stay was prolonged in comparison with patients without systemic inflammatory response syndrome. Conclusion: There exists an urgent need for more focused antimicrobial stewardship strategies and tools for standardised clinical assessment of acute bacterial skin and skin structure infection severity in patients who are unsuitable for beta-lactam antibiotics. This will lead to optimised antimicrobial treatment strategies and ensure effective healthcare resource utilisation. Competing Interests: Conflict of interest statement: The author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: J.A.T.S. was MSD advisory board member in 2015, A.G.-R. was MSD advisory board member during 2015–2016. R.D., M.A. and A.M. are employees of MSD.
Databáze:	MEDLINE
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