Self-regulation and the foraging gene ( PRKG1 ) in humans.

Autor:	Struk AA; Department of Psychology, University of Waterloo, Waterloo, ON N2M 2L9, Canada., Mugon J; Department of Psychology, University of Waterloo, Waterloo, ON N2M 2L9, Canada., Huston A; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada., Scholer AA; Department of Psychology, University of Waterloo, Waterloo, ON N2M 2L9, Canada., Stadler G; Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB24 3FX, United Kingdom.; Department of Psychology, Columbia University, New York, NY 10027., Higgins ET; Department of Psychology, Columbia University, New York, NY 10027., Sokolowski MB; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada., Danckert J; Department of Psychology, University of Waterloo, Waterloo, ON N2M 2L9, Canada; jdancker@uwaterloo.ca.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 05; Vol. 116 (10), pp. 4434-4439. Date of Electronic Publication: 2019 Feb 19.
DOI:	10.1073/pnas.1809924116
Abstrakt:	Foraging is a goal-directed behavior that balances the need to explore the environment for resources with the need to exploit those resources. In Drosophila melanogaster , distinct phenotypes have been observed in relation to the foraging gene ( for ), labeled the rover and sitter. Adult rovers explore their environs more extensively than do adult sitters. We explored whether this distinction would be conserved in humans. We made use of a distinction from regulatory mode theory between those who "get on with it," so-called locomotors, and those who prefer to ensure they "do the right thing," so-called assessors. In this logic, rovers and locomotors share similarities in goal pursuit, as do sitters and assessors. We showed that genetic variation in PRKG1 , the human ortholog of for , is associated with preferential adoption of a specific regulatory mode. Next, participants performed a foraging task to see whether genetic differences associated with distinct regulatory modes would be associated with distinct goal pursuit patterns. Assessors tended to hug the boundary of the foraging environment, much like behaviors seen in Drosophila adult sitters. In a patchy foraging environment, assessors adopted more cautious search strategies maximizing exploitation. These results show that distinct patterns of goal pursuit are associated with particular genotypes of PRKG1 , the human ortholog of for . Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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