| Autor: |
Koklu A; Department of Mechanical Engineering, Southern Methodist University, Dallas, TX, 75205, United States of America., Atmaramani R, Hammack A, Beskok A, Pancrazio JJ, Gnade BE, Black BJ |
| Jazyk: |
angličtina |
| Zdroj: |
Nanotechnology [Nanotechnology] 2019 Jun 07; Vol. 30 (23), pp. 235501. Date of Electronic Publication: 2019 Feb 18. |
| DOI: |
10.1088/1361-6528/ab07cd |
| Abstrakt: |
An ideal microelectrode array (MEA) design should include materials and structures which exhibit biocompatibility, low electrode polarization, low impedance/noise, and structural durability. Here, the fabrication of MEAs with indium tin oxide (ITO) electrodes deposited with self-similar gold nanostructures (GNS) is described. We show that fern leaf fractal-like GNS deposited on ITO electrodes are conducive for neural cell attachment and viability while reducing the interfacial impedance more than two orders of magnitude at low frequencies (100-1000 Hz) versus bare ITO. GNS MEAs, with low interfacial impedance, allowed the detection of extracellular action potentials with excellent signal-to-noise ratios (SNR, 20.26 ± 2.14). Additionally, the modified electrodes demonstrated electrochemical and mechanical stability over 29 d in vitro. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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