Effect of a Single Preoperative Dose of Oral Antibiotic to Reduce the Incidence of Surgical Site Infection Following Below-Knee Dermatological Flap and Graft Repair.

Autor: Rosengren H; School of Medicine, James Cook University, Townsville, Queensland, Australia; Skin Cancer College of Australasia, Brisbane, Queensland, Australia; Skin Repair Skin Cancer Clinic, Townsville, Queensland, Australia., Heal CF; School of Medicine, James Cook University, Mackay, Queensland, Australia., Buettner PG; Centre for Chronic Disease Prevention, James Cook University, Cairns, Queensland, Australia.
Jazyk: angličtina
Zdroj: Dermatology practical & conceptual [Dermatol Pract Concept] 2019 Jan 31; Vol. 9 (1), pp. 28-35. Date of Electronic Publication: 2019 Jan 31 (Print Publication: 2019).
DOI: 10.5826/dpc.0901a08
Abstrakt: Background: Surgical site infection (SSI) rates for below-knee dermatological surgery are unacceptably high, particularly following complex flap and graft closures. The role of antibiotic prophylaxis for these surgical cases is uncertain.
Objective: To determine whether SSI following complex dermatological closures on the leg could be reduced by antibiotic prophylaxis administered as a single oral preoperative dose.
Methods: A total of 115 participants were randomized to 2 g of oral cephalexin or placebo 40-60 minutes prior to surgical incision in a prospective, randomized, double-blind, placebo-controlled trial at a primary care skin cancer clinic in North Queensland, Australia.
Results: Overall 17/55 (30.9%) controls and 14/55 (25.5%) intervention participants developed infection (P = 0.525). There was no difference between the study groups in adverse symptoms that could be attributed to high-dose antibiotic administration (P = 1).
Conclusion: A single oral 2-g dose of cephalexin given before complex below-knee dermatological closure did not reduce SSI.
Competing Interests: Competing interests: The authors have no conflicts of interest to disclose.
Databáze: MEDLINE
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