The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies.

Autor: Rambo DF; Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Biegelmeyer R; Departamento do Medicamento, Faculdade de Farmácia, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil., Toson NSB; Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Dresch RR; Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Moreno PRH; Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil., Henriques AT; Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2019 May; Vol. 33 (5), pp. 1258-1276. Date of Electronic Publication: 2019 Feb 14.
DOI: 10.1002/ptr.6321
Abstrakt: Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively studied, mainly because of its alkaloids, which have pharmacological properties. References demonstrated that Erythrina spp. have a potential to act in the central nervous system, presenting anxiolytic and anticonvulsant properties already established. Phytochemical investigations confirmed the presence of tetracyclic alkaloids as the major compounds. However, other alkaloid classes have also been reported, including dimeric and trimeric substances, coupled through direct polymerization or two erythrinine units via an acetyl glucose. The present review covers the relevant literature from 1990 until 2017 and outlines the current data on chemical composition and preclinical and clinical studies on Erythrina species. Additionally, the quite striking analogy in the biosynthetic route of erythrin, morphinans, and Amaryllidaceae family alkaloids was also discussed.
(© 2019 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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