Flash Glucose Monitoring in Subjects with Diabetes on Hemodialysis: A Pilot Study.

Autor:	Javherani RS; Department of Clinical Nephrology and Critical Care, Chellaram Diabetes Institute, Pune, Maharashtra, India., Purandare VB; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Bhatt AA; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Kumaran SS; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India., Sayyad MG; Department of Biostatistics, Chellaram Diabetes Institute, Pune, Maharashtra, India., Unnikrishnan AG; Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.
Jazyk:	angličtina
Zdroj:	Indian journal of endocrinology and metabolism [Indian J Endocrinol Metab] 2018 Nov-Dec; Vol. 22 (6), pp. 848-851.
DOI:	10.4103/ijem.IJEM_520_18
Abstrakt:	Background: In patients with diabetes related end-stage renal disease (ESRD) on hemodialysis, blood glucose management can be challenging due to the kinetics of glucose and insulin in addition to other factors. The glucose monitoring systems which measure glucose levels continuously may be useful to study the glucose profile of patients with diabetes undergoing hemodialysis. Our study is designed to use ambulatory glucose profile to study the glucose pattern - during, before, and after a session of hemodialysis. Materials and Methods: Ten patients with type 2 diabetes with ESRD undergoing hemodialysis were recruited. Forty-eight glucose readings were recorded in a 12-h period which included 4 h each prior, during, and after the dialysis session with a flash glucose monitor (FreeStyle Libre-pro). The same 12 h time frame was also monitored on a non-dialysis day. Results: On the day of dialysis, the mean glucose level was significantly lower ( P = 0.013) compared to the day without dialysis (95 ± 12.7 mg/dl vs 194 ± 76.8 mg/dl). As compared to the pre-dialysis period, the mean blood glucose levels during dialysis were lower ( P = 0.004). As compared to the dialysis period, the mean blood glucose levels in the post-dialysis period were higher but did not reach statistical significance. Conclusion: In our study, subjects with type 2 diabetes on hemodialysis had lower glucose levels on the day of dialysis compared to non-dialysis day. Glucose levels showed a fall during hemodialysis and then a rise to higher levels after dialysis. Competing Interests: There are no conflicts of interest.
Databáze:	MEDLINE
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