Reduction of hospitalizations with diarrhea among children aged 0-5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine.

Autor: Ahmed MC; Laboratory of Microbiology and Molecular Biology, Department of Biology, University Mohammed V, Rabat, Morocco; Unity of Epidemiology and Diversity of Microorganisms, Department of Biology, Faculty of Sciences and Technology, University of Nouakchott El-Asriya, Nouakchott, Mauritania; Department of Epidemiology of Gastroenteritis, CDC Atlanta, USA. Electronic address: lemine1987@hotmail.fr., Heukelbach J; Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-140, Brazil; College of Public Health, Medical and Veterinary Sciences, Division of Tropical Health and Medicine, James Cook University, Townville, Queensland, Australia., Weddih A; Department of Pediatric, Faculty of Medicine, University of Nouakchott El-Asriya, Nouakchott, Mauritania; Department of Pediatric, Ministry of Health, Nouakchott, Mauritania., Filali-Maltouf A; Laboratory of Microbiology and Molecular Biology, Department of Biology, University Mohammed V, Rabat, Morocco., Sidatt M; Department of Pediatric, Faculty of Medicine, University of Nouakchott El-Asriya, Nouakchott, Mauritania; Department of Pediatric, Ministry of Health, Nouakchott, Mauritania., Makhalla K; Department of Pediatric, Ministry of Health, Nouakchott, Mauritania., Dahdi S; Department of Public Health, Faculty of Medicine, University of Nouakchott El-Asriya, Nouakchott, Mauritania., Cheikh Ahmed AC; Department of Mother and Child Health, Ministry of Health, Nouakchott, Mauritania., El-Mami MV; Unity of Epidemiology and Diversity of Microorganisms, Department of Biology, Faculty of Sciences and Technology, University of Nouakchott El-Asriya, Nouakchott, Mauritania., Tate JE; Department of Epidemiology of Gastroenteritis, CDC Atlanta, USA., Parashar UD; Department of Epidemiology of Gastroenteritis, CDC Atlanta, USA., Benhafid M; Unity of Gastroenteritis, Department of Virology, National Institute of Hygiene, Rabat, Morocco.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2019 Mar 07; Vol. 37 (11), pp. 1407-1411. Date of Electronic Publication: 2019 Feb 11.
DOI: 10.1016/j.vaccine.2019.01.078
Abstrakt: Introduction: Rotavirus vaccine was introduced in Mauritania in December 2014. We investigated hospitalizations with diarrhea during pre and post-vaccination periods among children aged 0-5 years in Nouakchott, the capital of Mauritania.
Methods: We conducted a retrospective review of hospital admission registries from November 1st 2012 through October 31th 2017 at all referral hospitals in Nouakchott. We described admissions of children aged 0-5 years by diagnosis, data of admission, age and sex, and compared the proportion of all childhood hospitalizations with diarrhea before and after rotavirus vaccine introduction.
Results: In total, 6552 (19%) of all 34,329 hospitalizations in 0-5 year-olds had diarrhea. Of these, 3523/16,952 (20.7%) were recorded during the pre-vaccine period, 1373/6897 (19.9%) during the transition period (November 2014-October 2015), and 1656/10,480 (15.8%) during the post-vaccination period. The proportion of all childhood hospitalizations with diarrhea during the pre-vaccine period was 22.6% among males and 18.7% among females. Approximately one third (32.3%) of hospitalizations with diarrhea occurred in children aged 6-11 months. During the post-vaccination period, the proportion of hospitalizations with diarrhea declined by 24%, and the highest reduction (74%) was observed in children aged 2 to 5 years (P < 0.001).
Conclusions: The proportion of childhood hospitalizations with diarrhea in Nouakchott was reduced by about one fourth after introduction of rotavirus vaccination in Mauritania, indicating a major impact for public health for children in the capital city.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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