| Autor: |
Hemu X; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551., Zhang X; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551., Tam JP; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2019 Apr 05; Vol. 21 (7), pp. 2029-2032. Date of Electronic Publication: 2019 Feb 14. |
| DOI: |
10.1021/acs.orglett.9b00151 |
| Abstrakt: |
A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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