MRI detects peripheral nerve and adjacent muscle pathology in non-systemic vasculitic neuropathy (NSVN).

Autor: Schneider C; Department of Neurology, University Hospital of Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany., Sprenger A; Department of Neurology, University Hospital of Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany., Weiss K; Philips Healthcare, Hamburg, Germany., Slebocki K; Department of Radiology, University of Cologne, Cologne, Germany., Maintz D; Department of Radiology, University of Cologne, Cologne, Germany., Fink GR; Department of Neurology, University Hospital of Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.; Institute of Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany., Henning TD; Department of Radiology, University of Cologne, Cologne, Germany.; Department of Neuroradiology, Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany., Lehmann HC; Department of Neurology, University Hospital of Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany. helmar.lehmann@uk-koeln.de., Lichtenstein T; Department of Radiology, University of Cologne, Cologne, Germany.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2019 Apr; Vol. 266 (4), pp. 975-981. Date of Electronic Publication: 2019 Feb 14.
DOI: 10.1007/s00415-019-09224-0
Abstrakt: Background: Diagnosis and disease monitoring of non-systemic vasculitic neuropathy (NSVN) are based on electrophysiological and clinical measures. However, these methods are insensitive to detect subtle differences of axonal injury. We here assessed the utility of a multiparametric MRI protocol to quantify axonal injury and neurogenic muscle damage in NSVN.
Methods: Ten NSVN patients and ten age-matched controls were investigated in this single-center prospective study. All participants were assessed by diffusion tensor imaging (DTI) of the tibial nerve and multiecho Dixon MRI of soleus and gastrocnemius muscles. These data were correlated with clinical and electrophysiological data.
Results: DTI scans of the tibial nerves of patients with NSVN showed significantly lower mean fractional anisotropy (FA) values (0.32 ± 0.02) compared to healthy controls (0.42 ± 0.01). FA values of NSVN patients correlated negatively with clinical measures of pain. Multiecho Dixon MRI scans revealed significantly higher intramuscular fat fractions in the soleus muscle (19.86 ± 6.18% vs. 5.86 ± 0.74%, p = 0.0015) and gastrocnemius muscle (26.09 ± 6.21% vs. 3.59 ± 0.82%, p = 0.0002) in NSVN patients compared to healthy controls.
Conclusion: Our data provide a proof of concept that MRI can render information about nerve integrity and muscle pathology in NSVN. Further studies are warranted to evaluate DTI and multiecho Dixon MRI as surrogate markers in NSVN.
Databáze: MEDLINE
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