Hyperoxygenation revitalizes Alzheimer's disease pathology through the upregulation of neurotrophic factors.
Autor: | Choi J; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea., Kwon HJ; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea., Lee JE; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea., Lee Y; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea., Seoh JY; Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Korea., Han PL; Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea.; Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. |
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Jazyk: | angličtina |
Zdroj: | Aging cell [Aging Cell] 2019 Apr; Vol. 18 (2), pp. e12888. Date of Electronic Publication: 2019 Feb 11. |
DOI: | 10.1111/acel.12888 |
Abstrakt: | Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ-induced pathology and progressive cognitive decline. The incidence of AD is growing globally, yet a prompt and effective remedy is not available. Aging is the greatest risk factor for AD. Brain aging proceeds with reduced vascularization, which can cause low oxygen (O (© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
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