The occurrence of cardiac abnormalities in canine steroid-responsive meningitis arteritis.

Autor: Spence S; Small Animal Hospital, University of Glasgow, Glasgow G61 1QH, UK., French A; Small Animal Hospital, University of Glasgow, Glasgow G61 1QH, UK., Penderis J; Vet Extra Neurology, Broadleys Veterinary Hospital, Stirling FK7 7LE, UK., Macfarlane L; North Downs Specialist Referrals, Bletchingley RH1 4QP, UK., Gutierrez-Quintana R; Small Animal Hospital, University of Glasgow, Glasgow G61 1QH, UK., Dickson L; Small Animal Hospital, University of Glasgow, Glasgow G61 1QH, UK., Holmes K, McLauchlan G; Fitzpatrick Referrals - Oncology and Soft Tissue, Surrey GU2 7AJ, UK.
Jazyk: angličtina
Zdroj: The Journal of small animal practice [J Small Anim Pract] 2019 Apr; Vol. 60 (4), pp. 204-211. Date of Electronic Publication: 2019 Feb 11.
DOI: 10.1111/jsap.12984
Abstrakt: Objectives: To document the prevalence of cardiac abnormalities in dogs with steroid-responsive meningitis arteritis and to assess resolution of these abnormalities following corticosteroid therapy.
Materials and Methods: Steroid-responsive meningitis arteritis was diagnosed based on signalment, physical examination findings, complete blood count, biochemistry and CSF analysis. Echocardiography, C-reactive protein and cardiac troponin I were measured in all cases before and 10 to 14 days after commencing corticosteroid therapy. Fibrinogen was also measured in a proportion of dogs.
Results: Fourteen dogs were prospectively enrolled. Increased cardiac troponin I was identified in five of 14 dogs and echocardiographic abnormalities were detected in 12 of 14 dogs, including spontaneous echo contrast (12 of 14), mild pericardial effusion (five of 14) and mildly decreased fractional shortening (five of 14). All dogs had increased C-reactive protein and fibrinogen was increased in 11 of 12. Corticosteroid treatment was associated with clinical improvement and normalisation of C-reactive protein in all dogs. The cardiac troponin I levels normalised in four of five and fibrinogen had normalised in all five dogs which were retested. Spontaneous echo contrast improved or completely resolved in 12 of 12 and pericardial effusion resolved in five of five dogs. Fractional shortening normalised in two of five dogs.
Clinical Significance: Cardiac changes are common in dogs with steroid-responsive meningitis arteritis and most resolve with therapy. Further investigation into the cause and significance of these changes is necessary in determining whether antithrombotic therapy or positive inotropic therapy is indicated.
(© 2019 The Authors. Journal of Small Animal Practice published by John Wiley & Sons Ltd on behalf of British Small Animal Veterinary Association.)
Databáze: MEDLINE
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