Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence.

Autor:	Liang H; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Tsui BY; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Ni H; Hangzhou YITU Healthcare Technology Co. Ltd, Hangzhou, China., Valentim CCS; Department of Thoracic Surgery/Oncology, First Affiliated Hospital of Guangzhou Medical University, China State Key Laboratory and National Clinical Research Center for Respiratory Disease, Guangzhou, China., Baxter SL; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Liu G; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Cai W; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Kermany DS; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Sun X; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Chen J; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., He L; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhu J; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Tian P; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Shao H; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zheng L; Guangzhou Kangrui Co. Ltd, Guangzhou, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China., Hou R; Guangzhou Kangrui Co. Ltd, Guangzhou, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China., Hewett S; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Li G; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Liang P; Hangzhou YITU Healthcare Technology Co. Ltd, Hangzhou, China., Zang X; Hangzhou YITU Healthcare Technology Co. Ltd, Hangzhou, China., Zhang Z; Hangzhou YITU Healthcare Technology Co. Ltd, Hangzhou, China., Pan L; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Cai H; Guangzhou Kangrui Co. Ltd, Guangzhou, China.; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China., Ling R; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Li S; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Cui Y; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Tang S; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Ye H; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Huang X; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., He W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Liang W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhang Q; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Jiang J; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Yu W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Gao J; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Ou W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Deng Y; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Hou Q; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Wang B; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Yao C; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Liang Y; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhang S; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Duan Y; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zhang R; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Gibson S; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zhang CL; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Li O; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zhang ED; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Karin G; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Nguyen N; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Wu X; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Wen C; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Xu J; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Xu W; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Wang B; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Wang W; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Li J; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Pizzato B; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Bao C; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Xiang D; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., He W; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., He S; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zhou Y; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Haw W; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA.; Veterans Administration Healthcare System, San Diego, CA, USA., Goldbaum M; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Tremoulet A; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Hsu CN; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Carter H; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA., Zhu L; Hangzhou YITU Healthcare Technology Co. Ltd, Hangzhou, China., Zhang K; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. kang.zhang@gmail.com.; Institute for Genomic Medicine, Institute of Engineering in Medicine, and Shiley Eye Institute, University of California, San Diego, La Jolla, CA, USA. kang.zhang@gmail.com.; Veterans Administration Healthcare System, San Diego, CA, USA. kang.zhang@gmail.com., Xia H; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. xiahumin@hotmail.com.
Jazyk:	angličtina
Zdroj:	Nature medicine [Nat Med] 2019 Mar; Vol. 25 (3), pp. 433-438. Date of Electronic Publication: 2019 Feb 11.
DOI:	10.1038/s41591-018-0335-9
Abstrakt:	Artificial intelligence (AI)-based methods have emerged as powerful tools to transform medical care. Although machine learning classifiers (MLCs) have already demonstrated strong performance in image-based diagnoses, analysis of diverse and massive electronic health record (EHR) data remains challenging. Here, we show that MLCs can query EHRs in a manner similar to the hypothetico-deductive reasoning used by physicians and unearth associations that previous statistical methods have not found. Our model applies an automated natural language processing system using deep learning techniques to extract clinically relevant information from EHRs. In total, 101.6 million data points from 1,362,559 pediatric patient visits presenting to a major referral center were analyzed to train and validate the framework. Our model demonstrates high diagnostic accuracy across multiple organ systems and is comparable to experienced pediatricians in diagnosing common childhood diseases. Our study provides a proof of concept for implementing an AI-based system as a means to aid physicians in tackling large amounts of data, augmenting diagnostic evaluations, and to provide clinical decision support in cases of diagnostic uncertainty or complexity. Although this impact may be most evident in areas where healthcare providers are in relative shortage, the benefits of such an AI system are likely to be universal.
Databáze:	MEDLINE
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