Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma.

Autor: Amini A; Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California.; Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado., Stokes WA; Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California., Jones BL; Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California., Sampath S; Department of Radiation Oncology, City of Hope National Cancer Center, Duarte, California., Kang RS; Division of Head and Neck Surgery, City of Hope National Cancer Center, Duarte, California., Gernon TJ; Division of Head and Neck Surgery, City of Hope National Cancer Center, Duarte, California., Maghami EG; Division of Head and Neck Surgery, City of Hope National Cancer Center, Duarte, California., Massarelli E; Department of Medical Oncology & Therapeutics Research, City of Hope National Cancer Center, Duarte, California., Bradley CJ; Department of Health Systems Management and Policy, Colorado Comprehensive Cancer Center, University of Colorado, Aurora, Colorado., Karam SD; Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2019 Jul; Vol. 41 (7), pp. 2299-2308. Date of Electronic Publication: 2019 Feb 09.
DOI: 10.1002/hed.25697
Abstrakt: Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility.
Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery.
Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses.
Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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