Peculiarities of nitric oxide donor drugs administration in obstetric practice.
| Autor: | Radzishevskaya EB; Kharkiv National Medical University, Kharkiv, Ukraine., Vyhivskyi OA; M.V. Lomonosov Moscow State University, Moscow, Russian Federation., Kalnytska VB; Kharkiv National Medical University, Kharkiv, Ukraine. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2018; Vol. 71 (9), pp. 1765-1769. |
| Abstrakt: | Objective: Introduction: Endothelial dysfunction is a universal mechanism for the development of many pathological conditions of the body. In obstetric practice, endothelial dysfunction underlies the development of many pathological conditions. Nitric oxide (NO) deficiency is a key element in endothelial dysfunction. The aim: To summarize the literature data on the effect of NO donor drugs on the state of fetoplacental complex in pregnancy complicated by obstetric and concomitant extragenital pathology, as well as their effect on the outcome of pregnancy. Patients and Methods: Materials and methods: The article presents an assessment of 39 literary sources, discussing the peculiarities of the use of various NO donor drugs. The study allowed the authors to characterize main functions of nitric oxide and pathogenesis of endothelial dysfunction. Modern methods for the correction of endothelial dysfunction in obstetrics are described. Conclusion: Conclusions: The presented review showed the role of nitric oxide in the development of endothelial dysfunction in various critical situations in obstetrics and therapeutic efficacy of administration of NO donor drugs in the correction of these disorders. Nitric oxide donors have a wide range of indications for use in obstetrics, and determination of their therapeutic possibilities requires further research. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|