| Autor: |
Nelson CA, Murua C, Jones JM, Mohler K, Zhang Y, Wiggins L, Kwit NA, Respicio-Kingry L, Kingry LC, Petersen JM, Brown J, Aslam S, Krafft M, Asad S, Dagher HN, Ham J, Medina-Garcia LH, Burns K, Kelley WE, Hinckley AF, Annambhotla P, Carifo K, Gonzalez A, Helsel E, Iser J, Johnson M, Fritz CL, Basavaraju SV |
| Jazyk: |
angličtina |
| Zdroj: |
Emerging infectious diseases [Emerg Infect Dis] 2019 Apr; Vol. 25 (4), pp. 767-775. Date of Electronic Publication: 2019 Apr 17. |
| DOI: |
10.3201/eid2504.181807 |
| Abstrakt: |
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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