Nephrotic syndrome co-existing with type 1 diabetes in a 12-year-old boy: Case report and literature review.

Autor:	Bawahab NS; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Safdar OY; Pediatric Nephrology Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Nagadi SA; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Saeedi AT; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Mohammed Hussain RW; Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	SAGE open medical case reports [SAGE Open Med Case Rep] 2019 Jan 31; Vol. 7, pp. 2050313X19827734. Date of Electronic Publication: 2019 Jan 31 (Print Publication: 2019).
DOI:	10.1177/2050313X19827734
Abstrakt:	Occurrence of early nephrotic syndrome in type 1 diabetes mellitus patients is extremely rare. Herein, we report the case of a 12-year-old boy who presented to our pediatric nephrology clinic with generalized edema. He had been diagnosed with type 1 diabetes mellitus at age 9 and had been treated with regular insulin. Examinations revealed normal kidney function, hypoalbuminemia, proteinuria (4+), hyperlipidemia, and low protein-to-creatinine ratio. The patient was diagnosed with idiopathic nephrotic syndrome and was empirically administered prednisolone for 12 weeks. Subsequently, prednisolone was tapered over 10-12 weeks. The patient showed good response to treatment. In conclusion, co-existence of nephrotic syndrome and type 1 diabetes mellitus may suggest an immunological basis; therefore, further studies are needed to investigate the relationship between these two conditions. Competing Interests: Declaration of conflict of interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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