Evaluation and application of a method for estimating nasal end-tidal O 2 fraction while administering supplemental O 2 .

Autor: Burk KM; Departments of Anesthesiology and Bioengineering, University of Utah, 84132, Salt Lake City, UT, USA., Kuck K; Departments of Anesthesiology and Bioengineering, University of Utah, 84132, Salt Lake City, UT, USA., Orr JA; Departments of Anesthesiology and Bioengineering, University of Utah, 84132, Salt Lake City, UT, USA. joseph.orr@hsc.utah.edu.
Jazyk: angličtina
Zdroj: Journal of clinical monitoring and computing [J Clin Monit Comput] 2019 Dec; Vol. 33 (6), pp. 1071-1080. Date of Electronic Publication: 2019 Feb 06.
DOI: 10.1007/s10877-019-00264-5
Abstrakt: This paper describes a method for estimating the oxygen enhanced end-tidal fraction of oxygen (F et O e ), the end-tidal fraction of oxygen (F et O 2 ) that is raised by administering supplemental oxygen. The paper has two purposes: the first is to evaluate the method's accuracy on the bench and in volunteers; the second purpose is to demonstrate how to apply the method to compare two techniques of oxygen administration. The method estimates F et O e by analyzing expired oxygen as oxygen washes out of the lung. The method for estimating F et O e was first validated using a bench simulation in which tracheal oxygen was measured directly. Then it was evaluated in 30 healthy volunteers and compared to the bench simulation. Bland-Altman analysis compared calculated and observed F et O e /F et O 2 measurements. After the method was evaluated, it was implemented to compare the F et O e obtained when administering oxygen using two different techniques (pulsed and continuous flow). A total of eighteen breath washout conditions were evaluated on the bench. F et O e estimates and tracheal F et O 2 had a mean difference of - 0.016 FO 2 with 95% limits of agreement from - 0.048 to 0.016 FO 2 . Thirteen breath washouts per volunteer were analyzed. Extrapolated and observed F et O 2 had a mean difference of - 0.001 FO 2 with 95% limits of agreement from - 0.006 to 0.004 FO 2 . Pulsed flow oxygen (PFO) achieved the same F et O e values as continuous flow oxygen (CFO) using 32.1% ± 2.27% (mean ± SD) of the CFO rate. This paper has demonstrated that the method estimates F et O 2 enhanced by administering supplemental oxygen with clinically insignificant differences. This paper has also shown that PFO can obtain F et O 2 similar to CFO using approximately one-third of the oxygen volume. After evaluating this method, we conclude that the method provides useful estimates of nasal F et O 2 enhanced by supplemental oxygen administration.
Databáze: MEDLINE
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