Moderate prevalence of HIV-1 transmitted drug resistance mutations in southern Brazil.

Autor: Bahls LD; Department of Clinical Analysis and Biomedicine, State University of Maringá, Av Colombo 5790, Maringá, Paraná, CEP 87020-900, Brazil. laribahls@gmail.com., Canezin PH; Department of Clinical Analysis and Biomedicine, State University of Maringá, Av Colombo 5790, Maringá, Paraná, CEP 87020-900, Brazil., Reiche EMV; Department of Pathology, Clinical and Toxicological Analysis, State University of Londrina, Londrina, Brazil., Fernandez JCC; Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Rio De Janeiro, Brazil., Dias JRC; Service Specializing in STD/AIDS (SAE) of Maringá, Department of Health of Maringá, Maringá, Brazil., Meneguetti VAF; Service Specializing in STD/AIDS (SAE) of Maringá, Department of Health of Maringá, Maringá, Brazil., Ueda LT; Service Specializing in STD/AIDS (SAE) of Londrina, Department of Health of Londrina, Londrina, Brazil., Bertolini DA; Department of Clinical Analysis and Biomedicine, State University of Maringá, Av Colombo 5790, Maringá, Paraná, CEP 87020-900, Brazil.
Jazyk: angličtina
Zdroj: AIDS research and therapy [AIDS Res Ther] 2019 Feb 05; Vol. 16 (1), pp. 4. Date of Electronic Publication: 2019 Feb 05.
DOI: 10.1186/s12981-019-0219-1
Abstrakt: Background: Despite the advances in therapy, the occurrence of drug-resistant human immunodeficiency virus type 1 (HIV-1) is a major obstacle to successful treatment. This study aimed to characterize the genetic diversity and to determine the prevalence of transmitted drug resistance mutations (TDRM) between individuals recently or chronically diagnosed with HIV-1 from Paraná, Brazil.
Methods: A total of 260 HIV-1 positive antiretroviral therapy-naïve patients were recruited to participate on the study, of which 39 were recently diagnosed. HIV-1 genotyping was performed using sequencing reaction followed by phylogenetic analyses to determine the HIV-1 subtype. TDRM were defined using the Calibrated Population Resistance Tool program.
Results: The HIV-1 subtypes frequency found in the studied population were 54.0% of subtype B, 26.7% subtype C, 6.7% subtype F1 and 12.7% recombinant forms. The overall prevalence of TDRM was 6.7%, including 13.3% for recently diagnosed subjects and 5.9% for the chronic group.
Conclusions: The prevalence of resistance mutations found in this study is considered moderate, thus to perform genotyping tests before the initiation of antiretroviral therapy may be important to define the first line therapy and contribute for the improvement of regional prevention strategies for epidemic control.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje