Topical application of cashew gum or chlorhexidine gel reduces overexpression of proinflammatory genes in experimental periodontitis.

Autor: Ferreira-Fernandes H; Laboratory of Genetics and Molecular Biology, Federal University of Piauí, Parnaíba, Brazil. Electronic address: hygorfernandes@ufpi.edu.br., Barros MAL; Laboratory of Genetics and Molecular Biology, Federal University of Piauí, Parnaíba, Brazil., Souza Filho MD; Laboratory of Genetics and Molecular Biology, Federal University of Piauí, Parnaíba, Brazil., Medeiros JVR; Laboratory of Experimental Physiopharmacology, Federal University of Piauí, Parnaíba, Brazil., Vasconcelos DFP; Laboratory of Histological Analysis and Preparation, Federal University of Piauí, Parnaíba, Brazil., Silva DA; Biotechnology and Biodiversity Center Research, Federal University of Piauí, Parnaíba, Brazil., Leódido ACM; Laboratory of Experimental Physiopharmacology, Federal University of Piauí, Parnaíba, Brazil., Silva FRP; Laboratory of Histological Analysis and Preparation, Federal University of Piauí, Parnaíba, Brazil., França LFC; Laboratory of Histological Analysis and Preparation, Federal University of Piauí, Parnaíba, Brazil., Di Lenardo D; Laboratory of Histological Analysis and Preparation, Federal University of Piauí, Parnaíba, Brazil., Yoshioka FKN; Laboratory of Genetics and Molecular Biology, Federal University of Piauí, Parnaíba, Brazil., Rey JA; Research Unit, Hospital Universitario La Paz, Madrid, Spain., Burbano RR; Laboratory of Molecular Biology, Ophir Loyola Hospital, Belém, Brazil., Pinto GR; Laboratory of Genetics and Molecular Biology, Federal University of Piauí, Parnaíba, Brazil.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2019 May 01; Vol. 128, pp. 934-940. Date of Electronic Publication: 2019 Feb 01.
DOI: 10.1016/j.ijbiomac.2019.02.002
Abstrakt: This study aimed to explore the effect of topically administering an orabase gel containing cashew gum (CG), a complex polysaccharide from Anacardium occidentale L., on the transcription of important proinflammatory (COX-2, NOS-2, INF-γ, OSCAR, and MYD88) and anti-inflammatory genes (IL-10, IL-4, and TGFβ1) in the gingival tissues of rats with ligature-induced periodontitis, compared to the effect observed upon topically applying a well-known antibiofilm agent (chlorhexidine) under the same experimental conditions. The gene expression profile in the gingival tissues of rats with periodontitis treated with CG did not statistically significantly differ from that observed in the group of animals treated with chlorhexidine. Results showed that CG is able to attenuate general inflammation in the periodontium by reducing the transcription of proinflammatory mediators in a MYD88-independent manner, and not by inducing the expression of anti-inflammatory factors. In conclusion, this study demonstrated that CG and chlorhexidine treatment reduced significantly the gene overexpression (COX-2, NOS-2, INF-γ, OSCAR, and TGFβ1) in the model of ligature-induced periodontitis.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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